Proteolysis and inflammation of the kidney glomerulus. [PDF]
Cell Tissue Res, 2021 Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease.
Demir F +7 more
europepmc +9 more sources
The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus. [PDF]
Int J Mol Sci, 2023 Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease ...
Mason WJ, Vasilopoulou E.
europepmc +7 more sources
Profiling and annotation of human kidney glomerulus proteome. [PDF]
Proteome Sci, 2013 BackgroundThe comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes.
Cui Z +10 more
europepmc +7 more sources
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. [PDF]
J Am Soc Nephrol, 2020 BACKGROUND The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved
Chung JJ +9 more
europepmc +3 more sources
Organogenesis of the kidney glomerulus [PDF]
Organogenesis, 2011 The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell ...
Jeffrey H. Miner
semanticscholar +5 more sources
The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]
Nature CommunicationsThe kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong +9 more
doaj +4 more sources
Segmental HOG: new descriptor for glomerulus detection in kidney microscopy image [PDF]
BMC Bioinformatics, 2015 The detection of the glomeruli is a key step in the histopathological evaluation of microscopic images of the kidneys. However, the task of automatic detection of the glomeruli poses challenges owing to the differences in their sizes and shapes in renal ...
Tsuyoshi Kato +6 more
semanticscholar +6 more sources
GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]
Commun Biol, 2021 The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J +6 more
europepmc +2 more sources
Analysis of the three dimensional structure of the kidney glomerulus capillary network [PDF]
Scientific Reports, 2019 The capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized.
Mark Terasaki +2 more
openalex +2 more sources
Determinants of Vascular Permeability in the Kidney Glomerulus* [PDF]
Journal of Biological Chemistry, 2002 The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney.
Y. Hamano +8 more
semanticscholar +4 more sources