Results 1 to 10 of about 33,604 (265)
Proteolysis and inflammation of the kidney glomerulus. [PDF]
Cell Tissue Res, 2021 AbstractProteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis.
Demir F +7 more
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The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus. [PDF]
Int J Mol Sci, 2023 Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression.
Mason WJ, Vasilopoulou E.
europepmc +4 more sources
The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]
Nature CommunicationsThe kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong +9 more
doaj +2 more sources
Profiling and annotation of human kidney glomerulus proteome. [PDF]
Proteome Sci, 2013 Abstract Background The comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes. This dataset, however, contained considerable redundancy resulting from identification criteria under which ...
Cui Z +10 more
europepmc +4 more sources
Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome.
PLoS ONE, 2023 Fibrillin-1 is a pivotal structural component of the kidney's glomerulus and peritubular tissue. Mutations in the fibrillin-1 gene result in Marfan syndrome (MFS), an autosomal dominant disease of the connective tissue.
Rodrigo Barbosa de Souza +8 more
doaj +1 more source
Cells, 2022 Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts have ...
Kimberly S. Collins +14 more
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Glycerol Improves Intracerebral Hemorrhagic Brain Injury and Associated Kidney Dysfunction in Rats
Antioxidants, 2021 In stroke patients, the development of acute kidney injury (AKI) is closely linked with worse outcomes and increased mortality. In this study, the interplay between post-stroke and AKI and treatment options was investigated in a rodent model of ...
Cheng-Yi Chang +7 more
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Perconditioning combined with postconditioning on kidney ischemia and reperfusion [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluate if combination of perconditioning and postconditioning provides improved renal protection compared to perconditioning alone in a model of renal reperfusion injury.
Felipe Lobato da Silva Costa +7 more
doaj +2 more sources
Determinants of Vascular Permeability in the Kidney Glomerulus [PDF]
Journal of Biological Chemistry, 2002 The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the human mutations in nephrin, podocin, alpha-actinin-4, COL4A3, and COL4A5 genes
Hamano, Yuki +8 more
openaire +3 more sources
Micromachines, 2021 Kidney microphysiological systems (MPS) serve as potentially valuable preclinical instruments in probing mechanisms of renal clearance and osmoregulation. Current kidney MPS models target regions of the nephron, such as the glomerulus and proximal tubule
Stephanie Y. Zhang, Gretchen J. Mahler
doaj +1 more source