Results 1 to 10 of about 1,045,240 (242)

Proteolysis and inflammation of the kidney glomerulus. [PDF]

Cell Tissue Res, 2021
Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease.
Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM, Wiech T, Rinschen MM.   +7 more
europepmc   +9 more sources

Profiling and annotation of human kidney glomerulus proteome. [PDF]

Proteome Sci, 2013
BackgroundThe comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes.
Cui Z, Yoshida Y, Xu B, Zhang Y, Nameta M, Magdeldin S, Makiguchi T, Ikoma T, Fujinaka H, Yaoita E, Yamamoto T.   +10 more
europepmc   +8 more sources

The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus. [PDF]

Int J Mol Sci, 2023
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression.
Mason WJ, Vasilopoulou E.
europepmc   +6 more sources

Organogenesis of the kidney glomerulus [PDF]

Organogenesis, 2011
The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell ...
Jeffrey H. Miner
semanticscholar   +6 more sources

Determinants of Vascular Permeability in the Kidney Glomerulus [PDF]

Journal of Biological Chemistry, 2002
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney.
Yuki Hamano, James A. Grunkemeyer, Akulapalli Sudhakar, Michael Zeisberg, Dominic Cosgrove, Roy Morello, Brendan Lee, Hikaru Sugimoto, Raghu Kalluri   +8 more
semanticscholar   +7 more sources

The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]

Nature Communications
The kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong, Victoria Driscoll, Sandrine Ettou, Keith Keller, Amha Atakilit, Mary E. Taglienti, Saurabh Kumar, Astrid Weins, Valerie A. Schumacher, Jordan A. Kreidberg   +9 more
doaj   +3 more sources

Endothelin and the Glomerulus in Chronic Kidney Disease [PDF]

Seminars in Nephrology, 2015
Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is expressed constitutively in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function.
Matthias Barton, Andrey Sorokin
semanticscholar   +5 more sources

Large-scale identification of genes implicated in kidney glomerulus development and function [PDF]

The EMBO Journal, 2006
To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of development, resulting in a catalogue of 6053 different genes.
Minoru Takemoto, Liqun He, Jenny Norlin, Jaakko Patrakka, Zhijie Xiao, Tatiana V. Petrova, Cecilia Bondjers, Julia Asp, Elisabet Wallgard, Ying Sun, Tore Samuelsson, Petter Mostad, Samuel Lundin, Naoyuki Miura, Yoshikazu Sado, Kari Alitalo, Susan E. Quaggin, Karl Tryggvason, Christer Betsholtz   +18 more
semanticscholar   +5 more sources

Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus [PDF]

International Journal of Molecular Sciences, 2019
Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often ...
Imane Abbas, Manale Noun, David Touboul, Dil Sahali, Alain Brunelle, Mario Ollero   +5 more
semanticscholar   +6 more sources

11β-Hydroxysteroid Dehydrogenase Type 2 Is Expressed in the Human Kidney Glomerulus [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
Our previous study demonstrated that the GR is expressed in the human kidney glomerulus. The function of the GR of glomerular cells might be affected by the concentration of intracellular glucocorticoids, which is modulated by 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2).
Saeko Kataoka, Akihiko Kudo, Hiroshi Hirano, Hayato Kawakami, Toshio Kawano, Eiji Higashihara, Hirotoshi Tanaka, F Delarue, Jean–Daniel Sraer, Tomoatsu Mune, Zygmunt S. Krozowski, Kunimasa Yan   +11 more
semanticscholar   +5 more sources