Clinical Pharmacology &Therapeutics, EarlyView.Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg +1 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz +5 more
wiley +1 more source
Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function
Proceedings of the National Academy of Sciences of the United States of America, 2003 O. Smithies
semanticscholar +1 more source
Oogenesis and germinal bed morphology of the brown anole (A. sagrei)
Developmental Dynamics, EarlyView.Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher +12 more
wiley +1 more source
Overlap of PR3-Positive ANCA-Associated Vasculitis and Primary Focal Segmental Glomerulosclerosis: A Case Report, Patient Perspective, and Review of the Literature. [PDF]
Can J Kidney Health DisLandsberg A +4 more
europepmc +1 more source
Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus.
Kidney International, 1999 Kunimasa Yan +14 more
semanticscholar +1 more source
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source
Podometrics as a translational platform for kidney health and disease: Oshima award address 2025. [PDF]
Clin Exp NephrolHaruhara K.
europepmc +1 more source
11β-Hydroxysteroid Dehydrogenase Type 2 Is Expressed in the Human Kidney Glomerulus
, 2002 Saeko Kataoka +11 more
semanticscholar +1 more source
Proteome studies, with emphasis on the kidney glomerulus
, 2012 Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding of the complex and dynamic nature of proteomes.
openaire +1 more source