Results 121 to 130 of about 36,605 (291)
Analysis of the three dimensional structure of the kidney glomerulus capillary network. [PDF]
Sci Rep, 2020 Terasaki M, Brunson JC, Sardi J.
europepmc +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Specific drug delivery to the kidney
, 2002 The mesangial cells of the glomerulus, the proximal tubular cells and the interstitial fibroblasts are the first choice targets for renal drug delivery since they play a pivotal role in many disease processes in the kidney.
de Zeeuw, D; id_orcid +4 more
core
Histological changes in muscles and kidney.
Light micrographs of a paraffin section stained with eosin (40x). a; muscles in -ve P0, b; muscles in P1, c; muscles in P2, d; muscles in P3, e; muscles in +veP0, f; kidney in -ve P0, g; kidney in P1, h; kidney in P2, i; kidney in P3, j; kidney in +ve P0.
Zakia Kanwal (6595427) +6 more
core +1 more source
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. [PDF]
J Am Soc Nephrol, 2020 Chung JJ +9 more
europepmc +1 more source
Beyond the Glomerulus—Kidney Tubule Markers and Diabetic Kidney Disease Progression [PDF]
Kidney International Reports, 2021 Bullen, Alexander L. +1 more
openaire +2 more sources
Animal Models and Experimental Medicine, EarlyView.Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny +12 more
wiley +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus
Kidney International, 1981 Electron microscopy and in vitro techniques were used to evaluate the morphologic responses of glomerular podocytes and glomerular endothelial cells to compounds that affect either cytoplasmic contractile elements or cytoplasmic microtubules. In response to in vitro incubation in the presence of cytochalasin D or B (compounds that inhibit contraction ...
openaire +2 more sources
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source