Results 111 to 120 of about 1,182,937 (319)

Pengaruh Pemberian Ekstrak Etanol Bawang Tiwai terhadap Hispatologi Ginjal Mencit

Journal of Tropical Pharmacy and Chemistry, 2012
The ethanolic extract from the bulb of Eleutherine americana was investigated for subacute toxicity in Balb/C male mice. The parameter used on this research is kidney histophatological.
Yurika Sastyarina
doaj   +1 more source

Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras [PDF]

, 2011
Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs).
Bing Huang, Jian Ge, JianFa Huang, Jie Yu, KaiJing Li, LiPing Guan, LiPing Lin, Min Zhang, QianYing Gao, ShaoChun Lin, Ting Luo, WeiHua Li, WenCong Wang, WenXin Zhang, XiaoPing Xu, XiGu Chen, XinMing Song, XinTao Huang, YiChi Zhang, YongLiang Lin, YongPing Li, ZhiChong Wang   +21 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Pengaruh Hiperglikemia terhadap Gambaran Histopatologis Glomerulus Mencit (Mus musculus Linn) yang Diinduksi Aloksan

Jurnal Kesehatan Andalas, 2015
AbstrakHiperglikemia menjadi ancaman serius karena berdampak buruk terhadap keluaran klinis karena dapat menyebabkan gangguan fungsi imun serta lebih rentan terkena infeksi, perburukan sistem kardiovaskuler, trombosis, peningkatan inflamasi, disfungsi ...
Melati Setia Ningsih, Eryati Darwin, Erlina Rustam   +2 more
doaj  

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model

Kidney International Reports
Introduction: Chronic changes in kidney histology are often approximated by using human vision but with limited accuracy. Methods: An interactive annotation tool trained an artificial intelligence (AI) model for segmenting structures on whole slide ...
Aleksandar Denic, Muhammad S. Asghar, Lucas Stetzik, Austin Reynolds, Jaidip M. Jagtap, Mahesh Kumar, Aidan F. Mullan, Andrew R. Janowczyk, Mariam P. Alexander, Maxwell L. Smith, Fadi E. Salem, Laura Barisoni, Andrew D. Rule   +12 more
doaj   +1 more source

Structural Alterations of the Glomerular Wall And Vessels in Early Stages of Diabetes Mellitus: Light and Transmission Electron Microscopic Study [PDF]

Libyan Journal of Medicine, 2007
Objective: The capillary changes at the initial stage of diabetes may show an angioarchitecture clearly different from those of later stages and,/or very severe glomerular change. However, the onset of alterations in the early phases is unclear.
Dkhil MA, Awadallah RS, Danfour MA
doaj  

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source