Results 131 to 140 of about 576,914 (292)

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Beyond the Glomerulus—Kidney Tubule Markers and Diabetic Kidney Disease Progression [PDF]

Kidney International Reports, 2021
Bullen, Alexander L., Garimella, Pranav S.   +1 more
openaire   +2 more sources

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Macro-and microscopic images of TB in the kidney.

, 2015
A. Nodules on outer surface of the right kidney and B. in the kidney parenchyma C. Tuberculoma in the kidney parenchyma D. Ziehl-Neelsen stain of a granuloma in the renal parenchyma showing glomeruli and tubules (x5) E. Microscopic zoom of indicated area
Janneke A. Cox (329523), Eric Van Marck (8462), Koen Van de Vijver (728115), Ann M. Nelson (329526), Andrew Kambugu (166978), Robert Colebunders (10697), Robert L. Lukande (329524), Yukari C. Manabe (249354), Sam Kalungi (728114)   +8 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus

Kidney International, 1981
Electron microscopy and in vitro techniques were used to evaluate the morphologic responses of glomerular podocytes and glomerular endothelial cells to compounds that affect either cytoplasmic contractile elements or cytoplasmic microtubules. In response to in vitro incubation in the presence of cytochalasin D or B (compounds that inhibit contraction ...
openaire   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

MPM imaging conditions in a kidney of a MWF rat in vivo.

, 2013
(A) Image of a superficial glomerulus (g) and a distal tubule (dt) in the kidney of a MWF rat. Proximal tubules (pt) showed green autofluorescence. Intra- and extraglomerular capillaries (arrows) were visualized with Texas Red-labeled 70 kDa dextran. The
Ina Maria Schießl (288061), Sophia Bardehle (288063), Hayo Castrop (118523)   +2 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Schip1 is expressed by glomerular podocytes.

, 2015
(A) RT-PCR shows SCHIP1 expression in both glomerulus and the kidney fraction lacking glomeruli. In the glomerulus, expression is mostly detected in FACS-sorted podocytes. As an internal control, expression levels of GAPDH were measured.
Christer Betsholtz (233390), Annika Wernerson (711647), Patricia Q. Rodriguez (500339), Ying Sun (23237), Ulf Hedin (544142), Timo Pikkarainen (447458), Karl Tryggvason (135087), Jaakko Patrakka (447459), Ljubica Perisic (544141), Kjell Hultenby (183330), Mathias Uhlén (2427553), Mark Lal (711646)   +11 more
core   +1 more source