Results 91 to 100 of about 1,184,470 (278)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Pengaruh Hiperglikemia terhadap Gambaran Histopatologis Glomerulus Mencit (Mus musculus Linn) yang Diinduksi Aloksan

Jurnal Kesehatan Andalas, 2015
AbstrakHiperglikemia menjadi ancaman serius karena berdampak buruk terhadap keluaran klinis karena dapat menyebabkan gangguan fungsi imun serta lebih rentan terkena infeksi, perburukan sistem kardiovaskuler, trombosis, peningkatan inflamasi, disfungsi ...
Melati Setia Ningsih, Eryati Darwin, Erlina Rustam   +2 more
doaj  

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Structural Alterations of the Glomerular Wall And Vessels in Early Stages of Diabetes Mellitus: Light and Transmission Electron Microscopic Study [PDF]

Libyan Journal of Medicine, 2007
Objective: The capillary changes at the initial stage of diabetes may show an angioarchitecture clearly different from those of later stages and,/or very severe glomerular change. However, the onset of alterations in the early phases is unclear.
Dkhil MA, Awadallah RS, Danfour MA
doaj  

Xstainer: A Novel Virtual Staining Tool Powered by Advanced Deep Learning Techniques

Advanced Intelligent Systems, EarlyView.
Xstainer is a deep learning–based virtual staining framework that converts hematoxylin and eosin‐stained whole slide images into multiple histochemical stains, including Masson's trichrome, Periodic acid‐Schiff, Jones methenamine silver, and Toluidine blue.
Fatma Nur Kinali, Derya Demir, Kutsev B. Ozyoruk, Yasin Almalioglu, Emre C. Kose, Drew F. K. Williamson, Gurdeniz Serin, G. Evren Keles, Banu S. Kumbaraci, Ceren Utku, Uguray P. Hacisalihoglu, Ilknur Turkmen, Figen Ozturk, Kayhan Basak, Yavuz Nuri Ertas, Mehmet Turan   +15 more
wiley   +1 more source

Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model

Kidney International Reports
Introduction: Chronic changes in kidney histology are often approximated by using human vision but with limited accuracy. Methods: An interactive annotation tool trained an artificial intelligence (AI) model for segmenting structures on whole slide ...
Aleksandar Denic, Muhammad S. Asghar, Lucas Stetzik, Austin Reynolds, Jaidip M. Jagtap, Mahesh Kumar, Aidan F. Mullan, Andrew R. Janowczyk, Mariam P. Alexander, Maxwell L. Smith, Fadi E. Salem, Laura Barisoni, Andrew D. Rule   +12 more
doaj   +1 more source

Does salinity make a difference—Kidney anatomy of Saimaa (Pusa saimensis) and Baltic ringed seals (Pusa hispida botnica)

The Anatomical Record, EarlyView.
Abstract As habitat salinity markedly differs between the endangered, freshwater‐dwelling Saimaa ringed seal (Pusa saimensis Nordquist, 1899) and the brackish water‐inhabiting Baltic ringed seal (Pusa hispida botnica Gmelin, 1788), we investigated whether this difference has resulted in morphological changes to their kidneys.
Heini Nihtilä, Juha Laakkonen
wiley   +1 more source

Ameliorative Effects of Two Forms of Pomegranate on Glomerular Transvertical Diameter in Steroid- Induced Kidney Damage in Mice

Journal of Rawalpindi Medical College, 2017
To observe the effects of Pomegranate juice (PJ) and Pomegranate peel extract (PPE) on glomerular transvertical diameter in steroid induced mice kidney damage. Methods: In this experimental study forty healthy adult mice (BALB/c strain), average weighing
Humaira Ali
doaj  

Deep-learning model for evaluating histopathology of acute renal tubular injury

Scientific Reports
Tubular injury is the most common cause of acute kidney injury. Histopathological diagnosis may help distinguish between the different types of acute kidney injury and aid in treatment.
Thi Thuy Uyen Nguyen, Anh-Tien Nguyen, Hyeongwan Kim, Yu Jin Jung, Woong Park, Kyoung Min Kim, Ilwoo Park, Won Kim   +7 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source