Results 91 to 100 of about 36,605 (291)

In-Depth Proteomic Profiling of the Normal Human Kidney Glomerulus Using Two-Dimensional Protein Prefractionation in Combination with Liquid Chromatography-Tandem Mass Spectrometry

, 2007
The kidney glomerulus plays a pivotal role in ultrafiltration of plasma into urine and also is the locus of kidney disease progressing to chronic renal failure.
Shigeki Sekiyama (8660832), Masahito Miyamoto (8660808), Lino M. Cuellar (8660823), Yutaka Yoshida (67904), Bo Xu (233514), Tetsuo Osawa (8660826), Yoshimi Nagasaka (8660814), Ying Zhang (40767), Hiroshi Sezaki (8660820), Masaaki Nameta (8660817), Eishin Yaoita (1311039), Kenjiro Kimura (360664), Izumi Taguchi (8660811), Hideo Morishita (8660829), Masayuki Tasaki (3572378), Tadashi Yamamoto (162395)   +15 more
core   +1 more source

Anatomical and Histological Study of Shark (Carcharhinus sorrah) Kidney

Biology, Medicine & Natural Product Chemistry, 2019
Sharks are sea water fishes belong to the class Chondrichthyes, Subclass Elasmobranchii. Sharks are cartilaginous fish that have a different osmoregulation process than any other sea water fish. Cartilaginous fish is the only vertebrate that can maintain
Hikmah Supriyati, Rakhmiyati Rakhmiyati, Muhammad Ja’far Luthfi   +2 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

IHC analysis of kidney sections from 5/6 nephrectomy mice for changes in glomerulus size and podocyte density.

, 2018
The kidneys (8 animals/treated groups) were harvested 5 weeks after initiation of treatment, fixed and stained as described in Methods. All representative images of podocyte nuclear staining in various treatments were at 400X magnification.
Yibin Zeng (2343964), Israel F. Charo (238848), Rajinder Singh (246689), Zhenhua Miao (4989665), Shichang Miao (1817041), Dale Newland (4989662), Xiaoping Zang (4989659), James J. Campbell (220592), Antoni Krasinski (4989668), Xiaoli Liu (165371), Bin Zhao (276445), Yu Wang (12152), Linda S. Ertl (4989653), Sreenivas Punna (2711104), Penglie Zhang (3037665), Thomas J. Schall (296690), Jeffrey McMahon (4989656), Ton Dang (667774)   +17 more
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Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

EBioMedicine, 2018
Background: During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation.
Danica Ryan, Megan R. Sutherland, Tracey J. Flores, Alison L. Kent, Jane E. Dahlstrom, Victor G. Puelles, John F. Bertram, Andrew P. McMahon, Melissa H. Little, Lynette Moore, Mary Jane Black   +10 more
doaj   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Towards a Glomerulus Nanoscale Spatial Atlas

, 2022
Thesis (Master's)--University of Washington, 2022The glomerulus is the basic filtration apparatus of the kidney, where thousands of the capillary-rich structures function to remove waste products from the blood stream while retaining macromolecules and ...
Ali, Adilijiang
core  

Molecular Signatures of Diabetic Kidney Disease Hiding in a Patient with Hypertension-Related Kidney Disease

, 2022
The Kidney Precision Medicine Project (KPMP) seeks to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI.
Jose R. Torrealba, Patel, Jiten, Emilio D. Poggio, Eadon, Michael T., Stephanie M. Grewenow, Robert D. Toto, Kidney Precision Medicine Project, Toto, Robert D., Grewenow, Stephanie M., Michael T. Eadon, Torrealba, Jose R., Alpers, Charles E., Jiten Patel, Bebiak, Jack, Charles E. Alpers, Jack Bebiak, Poggio, Emilio D.   +16 more
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Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Histological changes in kidney.

Light micrographs of a paraffin section stained with eosin (40x). a; kidney in -ve T0, b; kidney in +ve T0, c; kidney in T1, d; kidney in T2, e; kidney in T3, f; kidney in T4, g; kidney in T5, h; kidney in T6, I; kidney in T7.
Qandeel Minahal (17873640), Razia Liaqat (17873634), Wajeeha Komal (17873637), Shafaq Fatima (17419782), Aya S. Hussain (18388482)   +4 more
core   +1 more source