Results 91 to 100 of about 1,182,937 (319)

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

open access: yes, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim   +1 more
core   +1 more source

Multiple efferent arterioles of the human kidney glomerulus as observed by scanning electron microscopy of vascular casts.

open access: yesArchivum histologicum Japonicum = Nihon soshikigaku kiroku, 1985
About three thousand resin vascular casts of human renal glomeruli were examined with a scanning electron microscope, and two extremely rare glomeruli with quadruple or quintuple efferent arterioles were found.
T. Murakami   +3 more
semanticscholar   +1 more source

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

open access: yesAdvanced Materials, EarlyView.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang   +7 more
wiley   +1 more source

Changes in kidney function in a population with essential hypertension in real life settings [PDF]

open access: yes, 2017
Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a ...
Haidich, Anna-Bettina   +6 more
core  

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

open access: yes, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes   +42 more
core   +3 more sources

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

open access: yesAdvanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade   +19 more
wiley   +1 more source

Morphological Description and Histological Structure of Kidney in Barn Owl Tyto alba

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2017
  The morphological description and histological structure of Kidney in barn owl Tyto alba have been invesigated. The results of present study revealed that barn owl has pair of elongated solid kidney situated symmetrically on both sides of vertebral ...
Isrra A. A. Khadhim, Hussain A. Dauod
doaj  

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

open access: yesAdvanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai   +7 more
wiley   +1 more source

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]

open access: yes, 2018
IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael   +10 more
core  

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