Results 71 to 80 of about 36,605 (291)

Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys [PDF]

Journal of Extracellular Vesicles, 2016
Non-invasive tests to identify age and early disease-associated pathology within the kidney are needed. Specific populations of urinary extracellular vesicles (EVs) could potentially be used for such a diagnostic test.
Anne E. Turco, Wing Lam, Andrew D. Rule, Aleksandar Denic, John C. Lieske, Virginia M. Miller, Joseph J. Larson, Walter K. Kremers, Muthuvel Jayachandran   +8 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function

, 2003
Current interpretations of kidney function in terms of a coarse filter followed by a fine filter have difficulty explaining why the glomerulus does not clog. I propose, as an alternative, a semiquantitative hypothesis that assumes that the size-selective
Smithies, O.
core   +1 more source

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies [PDF]

, 2019
Chronic kidney disease (CKD) affects -10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function
Cechova, Sylvia, Charchar, Fadi J., Chu, Pei-Lun, Morris, Andrew P., Zhu, Gu, Cook, James P., Eales, James, Larsson, Anders, Kamatani, Yoichiro, van der Most, Peter J.; id_orcid, Montgomery, Grant W., Kubo, Michiaki, Sundstrom, Johan, Snieder, Harold; id_orcid, Kramer, Holly J., Wacher-Rodarte, Niels, Le, Thu H., Wu, Haojia, Akbarov, Artur, Raffel, Leslie J., Lindgren, Cecilia M., Nadkarni, Girish N., Sacco, Ralph L., Papanicolaou, George J., Smith, George Davey, Stark, Holger, Snieder, Harold, Ipp, Eli, Bottinger, Erwin P., Lu, Yingchang, Hai, Yang, Sanchez, Elena, Hemani, Gibran, Stilp, Adrienne M., Kiryluk, Krzysztof, de Borst, Martin H., Damman, Jeffrey, Haessler, Jeffrey, Buchanan, Thomas A., Guo, Xiuqing, Blanton, Susan H., van der Most, Peter J., Valladares-Salgado, Adan, Arnlov, Johan, Gaulton, Kyle J., Gharavi, Ali G., Dueker, Nicole D., Heath, Andrew C., Mychaleckyj, Josyf C., Mahajan, Anubha, Giedraitis, Vilmantas, de Borst, Martin H.; id_orcid, Madden, Pamela A. F.   +52 more
core   +1 more source

Significance of suPAR in glomerular diseases

Linchuang shenzangbing zazhi, 2020
The soluble urokinase-type plasminogen activator receptor(suPAR) is a new type of biomarkers, and can be used for a variety of diagnosis, evaluation and prognosis of many diseases.
RUAN Dong-dong, YUAN Jun
doaj  

Immune Cell Infiltrate in Chronic-Active Antibody-Mediated Rejection

Frontiers in Immunology, 2020
Background: Little is known about immune cell infiltrate type in the kidney allograft of patients with chronic-active antibody-mediated rejection (c-aABMR).Methods: In this study, multiplex immunofluorescent staining was performed on 20 cases of biopsy ...
Kasia A. Sablik, Ekaterina S. Jordanova, Noelle Pocorni, Marian C. Clahsen-van Groningen, Michiel G. H. Betjes   +4 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Hubungan Kejadian Anemia dengan Penyakit Ginjal Kronik pada Pasien yang Dirawat di Bagian Ilmu Penyakit Dalam RSUP dr M Djamil Padang Tahun 2010.

Jurnal Kesehatan Andalas, 2016
AbstrakAnemia merupakan salah satu masalah utama pada pasien penyakit ginjal kronik. Tinggi rendahnya laju filtrasi glomerulus mempengaruhi kejadian anemia pada penyakit ginjal kronik.
Rahmat Hidayat, Syaiful Azmi, Dian Pertiwi3 Pertiwi   +2 more
doaj  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Epithelial-mesenchymal feedback signalling during vertebrate organogenesis : genetic analysis of BMP-Gremlin1 antagonistic interactions [PDF]

, 2010
Branching morphogenesis of the metanephric kidney relies on an intricate molecular system that controls a highly regulated developmental program. Metanephric kidney organogenesis involves a complex system of epithelial mesenchymal interactions that ...
Gonçalves, Alexandre
core   +1 more source