Results 71 to 80 of about 576,914 (292)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Hubungan antara Lama Menjalani Terapi Hemodialisis dengan Kualitas Hidup pada Pasien Chronic Kidney Disease di RS M. Djamil Padang

Jurnal Ilmu Kesehatan Indonesia
Latar Belakang: Penyakit chronic kidney disease (CKD) merupakan abnormalitas struktur dan fungsi ginjal dengan atau tanpa penurunan laju filtrasi glomerulus (LFG) atau kadar glomerulus kurang dari 60 mL/menit/1,73m2 yang bersifat ireversibel.
Hanifah Nabilah, Rudy Afriant, Yaslinda Yaunin, Irza Wahid, Eldi Sauma   +4 more
doaj   +1 more source

Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys [PDF]

Journal of Extracellular Vesicles, 2016
Non-invasive tests to identify age and early disease-associated pathology within the kidney are needed. Specific populations of urinary extracellular vesicles (EVs) could potentially be used for such a diagnostic test.
Anne E. Turco, Wing Lam, Andrew D. Rule, Aleksandar Denic, John C. Lieske, Virginia M. Miller, Joseph J. Larson, Walter K. Kremers, Muthuvel Jayachandran   +8 more
doaj   +1 more source

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

, 2017
An in vitro model of the human kidney glomerulus — the major site of blood filtration — could facilitate drug discovery and illuminate kidney-disease mechanisms.
Kristen Roberts, Sauveur S. F. Jeanty, Samira Musah, Tohid Fatanat-Didar, Jeanty, Sauveur, Sandeep Koshy, Ingber, Donald, Richard Novak, James C. Weaver, Seyoon Chung, Church, George, Thomas C. Ferrante, Tadanori Mammoto, Ingram, Miles, Chung, Seyoon, Musah, Samira, Hirano-Kobayashi, Mariko, Mammoto, Tadanori, George M. Church, Miles Ingram, Weaver, James, Novak, Richard, Mariko Hirano-Kobayashi, Donald E. Ingber, Roberts, Kristen, Akiko Mammoto, Mammoto, Akiko, Fatanat-Didar, Tohid, Ferrante, Thomas, Koshy, Sandeep   +29 more
core   +1 more source

Localization of the Clta-eGFP signal in kidney sections.

, 2022
(A) Clta-eGFP reporter kidney section stained for aquaporin-1 (AQP1) showing that the Clta-eGFP signal is localized to proximal tubule. (B) Clta-eGFP reporter kidney sections stained for aquaporin-2 (AQP2) showing that the Clta-eGFP is not detectable in ...
Nisha Veits (13850895), Roger Sandhoff (24498), Donato Sardella (13850892), Robert Engel (2135500), Richard Jennemann (388266), Elisabeth Grimm (13850886), Ulrike Engel (144037), Katrin I. Willig (2170111), Luca Bordoni (13850898), Felix Bestvater (4779366), Franciscus van der Hoeven (13850889), Ina Maria Schiessl (13850901), Kai Schönig (261411), Elisabetta Ada Cavalcanti-Adam (791995)   +13 more
core   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

Significance of suPAR in glomerular diseases

Linchuang shenzangbing zazhi, 2020
The soluble urokinase-type plasminogen activator receptor(suPAR) is a new type of biomarkers, and can be used for a variety of diagnosis, evaluation and prognosis of many diseases.
RUAN Dong-dong, YUAN Jun
doaj  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Hubungan Kejadian Anemia dengan Penyakit Ginjal Kronik pada Pasien yang Dirawat di Bagian Ilmu Penyakit Dalam RSUP dr M Djamil Padang Tahun 2010.

Jurnal Kesehatan Andalas, 2016
AbstrakAnemia merupakan salah satu masalah utama pada pasien penyakit ginjal kronik. Tinggi rendahnya laju filtrasi glomerulus mempengaruhi kejadian anemia pada penyakit ginjal kronik.
Rahmat Hidayat, Syaiful Azmi, Dian Pertiwi3 Pertiwi   +2 more
doaj  

Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4

Clinical Proteomics, 2011
Purpose The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) rats, and to discuss the relation ...
Akimoto Yoshihiro, Miura Yuri, Toda Tosifusa, Wolfert Margreet A, Wells Lance, Boons Geert-Jan, Hart Gerald W, Endo Tamao, Kawakami Hayato   +8 more
doaj   +1 more source