Results 61 to 70 of about 576,914 (292)

EXPERIMENT ON EFFECTS OF LOE-PROTEIN DIET SUPPLEMENTED WITH α-KETOACIDS ON HYPERTROPHY OF DIABETIC GLOMERULUS AND ITS RELATIONSHIP WITH THE LEVEL OF CYCLIN KINASE INHIBITOR P27

Kidney Research and Clinical Practice, 2012
Low-protein diet supplemented with α-keto acids was reported to have renoprotective roles in diabetic nephropathy via inhibiting glomerular hypertrophy, however, the mechanism has not yet been fully clarified.
Yi Zhou, Weijie Yuan, Ting Dong, Ling Wang   +3 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies [PDF]

, 2019
Chronic kidney disease (CKD) affects -10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function
Cechova, Sylvia, Charchar, Fadi J., Chu, Pei-Lun, Morris, Andrew P., Zhu, Gu, Cook, James P., Eales, James, Larsson, Anders, Kamatani, Yoichiro, van der Most, Peter J.; id_orcid, Montgomery, Grant W., Kubo, Michiaki, Sundstrom, Johan, Snieder, Harold; id_orcid, Kramer, Holly J., Wacher-Rodarte, Niels, Le, Thu H., Wu, Haojia, Akbarov, Artur, Raffel, Leslie J., Lindgren, Cecilia M., Nadkarni, Girish N., Sacco, Ralph L., Papanicolaou, George J., Smith, George Davey, Stark, Holger, Snieder, Harold, Ipp, Eli, Bottinger, Erwin P., Lu, Yingchang, Hai, Yang, Sanchez, Elena, Hemani, Gibran, Stilp, Adrienne M., Kiryluk, Krzysztof, de Borst, Martin H., Damman, Jeffrey, Haessler, Jeffrey, Buchanan, Thomas A., Guo, Xiuqing, Blanton, Susan H., van der Most, Peter J., Valladares-Salgado, Adan, Arnlov, Johan, Gaulton, Kyle J., Gharavi, Ali G., Dueker, Nicole D., Heath, Andrew C., Mychaleckyj, Josyf C., Mahajan, Anubha, Giedraitis, Vilmantas, de Borst, Martin H.; id_orcid, Madden, Pamela A. F.   +52 more
core   +2 more sources

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Biomarker Acute Kidney Injury (AKI) pada Sepsis

Jurnal Kesehatan Andalas, 2018
Sepsis didefinisikan sebagai infeksi bersama dengan manifestasi sistemik dari infeksi. Sepsis berat adalah penyebab 50% kasus acute kidney injury (AKI) pada pasien kritis.
Dional Setiawan, Harnavi Harun, Syaiful Azmi, Drajad Priyono   +3 more
doaj   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Potential of karamunting (Rhodomyrtus tomentosa) fraction against kidney damage in diabetic rats

Herba Polonica, 2021
Introduction: Karamunting (Rhodomyrtus tomentosa) is Indonesian native plant that contains high anti-oxidant compounds with the potential to suppress oxidative stress activity in cells. This study is the first research to specifically explore the role of
Saleh Mgs Irsan, Hidayat Rachmat, Febriyanto Geri, Parisa Nita   +3 more
doaj   +1 more source

Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function [PDF]

, 2003
Current interpretations of kidney function in terms of a coarse filter followed by a fine filter have difficulty explaining why the glomerulus does not clog. I propose, as an alternative, a semiquantitative hypothesis that assumes that the size-selective
Smithies, O.
core   +1 more source

Rho GTPases in kidney physiology and diseases

, 2021
International audienceRho family GTPases are molecular switches best known for their pivotal role in dynamic regulation of the actin cytoskeleton, but also of cellular morphology, motility, adhesion and proliferation.
Hervé, Claude, Hauet, Thierry, Bourmeyster, Nicolas, Steichen, Clara, Hervé, Jean-Claude, Claude Hervé, Nicolas Bourmeyster, Thierry, Hauet, Claude, Herve Jean, Clara Steichen, Thierry Hauet, Clara, Steichen, Nicolas, Bourmeyster   +12 more
core   +1 more source