Results 11 to 20 of about 1,045,240 (242)

Identification and localization of novel genes preferentially expressed in human kidney glomerulus [PDF]

Nephrology, 2008
SUMMARYAim:  To find novel genes abundantly and preferentially expressed in human glomerulus, we constructed a glomerular cDNA library and verified the reliability of our database by comparison with the Stanford Microarray Database (SMD), followed by reverse transcription polymerase chain reaction (RT‐PCR) and in situ hybridization (ISH).Methods:  RNA ...
Lino Muñoz Cuéllar, Hidehiko Fujinaka, Keiko Yamamoto, Masahito Miyamoto, Masayuki Tasaki, Linning Zhao, Tamer Ahmed Ismail, Eishin Yaoita, Yutaka Yoshida, Tadashi Yamamoto   +9 more
semanticscholar   +5 more sources

Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus [PDF]

Journal of Controlled Release, 2017
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins in the urine) diseases.
Riccardo Bruni, Paolo Possenti, Carlotta Bordignon, Min Li, Stefania Ordanini, Piergiorgio Messa, Maria Pia Rastaldi, Francesco Cellesi   +7 more
semanticscholar   +5 more sources

Segmental HOG: new descriptor for glomerulus detection in kidney microscopy image [PDF]

BMC Bioinformatics, 2015
The detection of the glomeruli is a key step in the histopathological evaluation of microscopic images of the kidneys. However, the task of automatic detection of the glomeruli poses challenges owing to the differences in their sizes and shapes in renal ...
Tsuyoshi Kato, Raissa Relator, Hayliang Ngouv, Yoshihiro Hirohashi, T. Kakimoto, Kinya Okada   +5 more
semanticscholar   +9 more sources

Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus [PDF]

Kidney International, 1999
The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR).
Kunimasa Yan, Akihiko Kudo, Hiroshi Hirano, Takashi Watanabe, Tetsuya Tasaka, Saeko Kataoka, Noriko Nakajima, Yukino Nishibori, Toru Shibata, Takao Kohsaka, Eiji Higashihara, Hirotoshi Tanaka, Hidehiro Watanabe, Toshihiko Nagasawa, Shouichi Awa   +14 more
semanticscholar   +5 more sources

Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus

Kidney International, 1981
Electron microscopy and in vitro techniques were used to evaluate the morphologic responses of glomerular podocytes and glomerular endothelial cells to compounds that affect either cytoplasmic contractile elements or cytoplasmic microtubules. In response to in vitro incubation in the presence of cytochalasin D or B (compounds that inhibit contraction ...
Peter M. Andrews
semanticscholar   +5 more sources

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]

Commun Biol, 2021
The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J, Chesor M, Kuzmuk V, Johnson T, Satchell SC, Welsh GI, Saleem MA.   +6 more
europepmc   +2 more sources

Preferential transport of non-enzymatically glucosylated ferritin across the kidney glomerulus

Kidney International, 1985
We have examined the significance of carbohydrate structure to the transglomerular passage of proteins. Carbohydrate-free (non-glycosylated) ferritin, prepared by Concanavalin-A-sepharose affinity chromatography, was perfused into rat kidneys, and was observed to be restricted from transglomerular transport and to accumulate within the lamina rara ...
Stuart K. Williams, Robert K. Siegal
semanticscholar   +5 more sources

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury.

J Am Soc Nephrol, 2020
BACKGROUND The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved
Chung JJ, Goldstein L, Chen YJ, Lee J, Webster JD, Roose-Girma M, Paudyal SC, Modrusan Z, Dey A, Shaw AS.   +9 more
europepmc   +2 more sources

Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis [PDF]

Kidney International, 2004
Myocilin is a 55 to 57 kD secreted glycoprotein and member of the olfactomedin protein family. It is expressed in high amounts in the outflow tissues of the aqueous humor in the eye where it is supposed to contribute to outflow resistance. Myocilin is mutated in some forms of primary open angle glaucoma and affected patients show very high intraocular ...
Andreas Goldwich, Daniela C. Baulmann, Andreas Ohlmann, Cassandra Fluugel-Koch, Harald O. Schöcklmann, Ernst R. Tamm   +5 more
openalex   +4 more sources

Analysis of the three dimensional structure of the kidney glomerulus capillary network [PDF]

Scientific Reports, 2019
The capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized.
M. Terasaki, J. C. Brunson, Justin Sardi
semanticscholar   +6 more sources