Results 51 to 60 of about 944,175 (254)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Mesenchymal Tumors of the Kidney in Adults

Kidney Cancer
Mesenchymal neoplasms of the kidney encompass a wide range of tumor types with heterogeneous clinical, histologic, and molecular features. Given their rarity relative to renal epithelial neoplasms, diagnosis may be challenging.
William J. Anderson
doaj   +1 more source

Navigating the complexity of Wilms tumors in pediatrics: diagnostic challenges for better treatment

Surgical and Experimental Pathology
Most pediatric kidney tumors clinically present as an abdominal mass, typically detected by the child’s caregivers and later confirmed through imaging tests.
Mariana Andozia Morini, Isabela Werneck da Cunha   +1 more
doaj   +1 more source

Fibrillary Glomerulonephritis and Multiple Myeloma: A Case Report and Literature Review

Case Reports in Oncology
Introduction: Fibrillary glomerulonephritis (FGN) is a rare form of immune complex-mediated primary glomerular disease frequently coexisting with malignancies or autoimmune diseases.
Taiki Ishida, Ken Morita, Yosuke Masamoto, Hideaki Mizuno, Kazuki Taoka, Hiroyuki Abe, Motoki Odawara, Yosuke Hirakawa, Masaomi Nangaku, Mineo Kurokawa   +9 more
doaj   +1 more source

Metastatic neoplasms to the breast

, 2023
Objective: When the clinical presentation is related to the metastatic mass and a radiologically solitary tumor focus is detected, especially in cases where clinical information is not taken into account or is insufficient, if a possible metastatic ...
Özsen, Mine, Tolunay, Şahsine, Polatkan, Seyit Ali Volkan, Şenol, Kazım, Gökgöz, Mustafa Şehsuvar   +4 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Primitive neuroectodermal tumor of the kidney: report of a patient

Acta Médica del Centro, 2012
Kidney neoplasms amount to 2-3% of total neoplasms; among them, primitive neuroectodermal tumors are not common. The case of a 28-year-old female patient, with a history of bronchial asthma, who went to see the doctor because she incidentally noticed an ...
Julio Vigil Quiñones, Paulino E. Hernández Hernández, Carmen Garrido Arce   +2 more
doaj  

Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen

Renal Failure
The long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases.
Dianjie Zeng, Lingfei Zhu, Li Shi, Yuxi Wang, Jiachen Liu, Yi Peng, Xiaokun Zhao, Yinhuai Wang, Liya Sun, Haiqing He   +9 more
doaj   +1 more source

Isolated Renal Metastasis from Neuroendocrine Tumor: How Rare is Rare? A Case Report and Review of the Literature

Journal of Urological Surgery, 2016
Neuroendocrine tumors (NETs) are epithelial neoplasms arising from neuroendocrine cells that are widely distributed throughout the body. The kidney is a rare site for primary NETs and is even rarer as a metastatic site.
Irma Lengu, Santhi Ganesan
doaj   +1 more source