Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial. [PDF]
, 2023 BACKGROUND: The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression.
EMPA-KIDNEY Collaborative Group
core +1 more source
Primitive neuroectodermal tumor of the kidney: report of a patient
Acta Médica del Centro, 2012 Kidney neoplasms amount to 2-3% of total neoplasms; among them, primitive neuroectodermal tumors are not common. The case of a 28-year-old female patient, with a history of bronchial asthma, who went to see the doctor because she incidentally noticed an ...
Julio Vigil Quiñones +2 more
doaj
Renal FailureThe long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases.
Dianjie Zeng +9 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma [PDF]
, 2012 Background: Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical ...
Antony C P Riddick +35 more
core +3 more sources
Discover OncologyBackground Urologic neoplasms are considered to pose a serious threat to patients’ lives and quality of life. Analyzing and describing the global disease burden of urologic neoplasms is necessary.
Zhao Yang +4 more
doaj +1 more source
Risk factors and pathogenesis of malignant neoplasms in kidney transplant recipients
Трансплантология (Москва)Background. Kidney transplant recipients have a significantly increased risk of developing malignancies compared with the general population. Moreover, recipients living in different regions of the world have different rates and patterns of cancer ...
R. N. Trushkin +3 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Sociodemographic characteristics and clinical features of patients with adult polycystic kidney disease undergoing hemodialysis [PDF]
, 2013 Aims: To analyze the socio-demographic and clinical characteristics of patients with adult polycystic kidney disease admitted to hemodialysis services in Northwestern Paraná state, Brazil.
Tsuneto, Luiza Tamie +13 more
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