Results 161 to 170 of about 18,915 (265)

Bioactivity of <i>Ribes nigrum</i> L. Juice and Waste Extracts: Chemical Composition, Antioxidant, and Antiproliferative Properties. [PDF]

Plants (Basel)
Trajković M, Miladinović B, Mihailović D, Najman S, Milutinović M, Randjelović M, Jovanović M, Kitić N, Šavikin K, Kitić D.   +9 more
europepmc   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Irisin-Driven AMPK-PGC-1α Activation Underlies the Renoprotective Effects of Swimming Exercise in Obesity-Induced Kidney Injury. [PDF]

Biomolecules
Hanafy SM, Zakaria SS, Jumaa MI, Al-Dhelaan RA, Yousef EM.   +4 more
europepmc   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

WDR72 Is Required for Urinary Acidification and Normal H⁺-ATPase Activity in Intercalated Cells in Mice. [PDF]

Acta Physiol (Oxf)
Auwerx H, Busch-Dohr M, Li X, Wagner CA, Bourgeois S.   +4 more
europepmc   +1 more source

Alport Syndrome is a Partial Tubulointerstitial Disease of the Kidney. [PDF]

Kidney Int Rep
Loderbauer L, Knaup KX, Reisenbüchler D, Kaiser N, Naas S, Schneider K, Wopperer FJ, Wiesener A, Pasutto F, Schiffer M, Daniel C, Broeker KAE, Merhof D, Buettner-Herold M, Wiesener MS.   +14 more
europepmc   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Kidney organoid vascularization: current advancements in the field. [PDF]

Regen Ther
Shioda H, Tang TH, Raykhel I, Sakai Y, Nishikawa M.   +4 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

A Mouse Model for "Definitive" Polyomavirus Nephropathy with End-Organ Injury. [PDF]

Viruses
Nickeleit V, Butcher D, Thompson B, Davis VG, Mieczkowski P, Singh HK.   +5 more
europepmc   +1 more source