Nigella sativa Infusion as an Antioxidant Agent Against Gentamicin-Induced Kidney Damaged in Mice
Althea Medical Journal, 2014 Background: Gentamicin is one of the most common antibiotics related to nephrotoxicity. It has been proposed that the nephrotoxicity is associated with the generation of the reactive oxygen species.
Hamsiah binti Halim +2 more
doaj
Diabetes, Obesity and Metabolism, EarlyView.Abstract Background Sodium‐glucose cotransporter (SGLT) 2 inhibitors attenuate fasting glomerular hyperfiltration in people with type 2 diabetes (T2D). However, SGLT2‐inhibition increases glucagon levels, which facilitate postprandial hyperfiltration.
Michaël J. B. van Baar +10 more
wiley +1 more source
High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects [PDF]
, 2016 Cuyckens, Filip +5 more
core +1 more source
Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis
Advanced ScienceMitochondrial dysfunction is a key event driving the maladaptive repair of tubular epithelial cells during the transition from acute kidney injury to chronic kidney disease (CKD).
Xiaohan Liu +12 more
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims We assessed the effects of dapagliflozin on natriuresis and blood pressure in patients with type 2 diabetes and chronic kidney disease (CKD) and evaluated the consistency of these effects across patients with type 2 diabetes without CKD and CKD without type 2 diabetes.
Jelle M. Beernink +16 more
wiley +1 more source
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]
, 2019 Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song +12 more
core +2 more sources
d‐amino acids: new functional insights
The FEBS Journal, EarlyView.This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni +5 more
wiley +1 more source
Ultrastructure of the reproductive system of the black swamp snake (\u3ci\u3eSeminatrix pygaea\u3c/i\u3e). Part III. The sexual segment of the male kidney. [PDF]
, 2002 In mature male snakes and lizards, a distal portion of the nephron is hypertrophied in relation to its appearance in females and immature males. This sexual segment of the male kidney apparently provides seminal fluid that is mixed with sperm and ...
Sever, David M.
core +1 more source
The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach
Insect Molecular Biology, EarlyView.Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins +7 more
wiley +1 more source
The ‘nephrotoxins’ were stopped: what is in a name and its impact on kidney and cardiac health?
Internal Medicine Journal, EarlyView.Abstract The term ‘nephrotoxin’ is often imprecisely applied to medications that are not inherently toxic to the kidneys, including renin‐angiotensin‐aldosterone system inhibitors, sodium‐glucose co‐transporter 2 inhibitors, diuretics and metformin. These drugs are frequently included in ‘sick day rules’ and may be prematurely discontinued during acute
Catherine Mao, Bobby Chacko
wiley +1 more source