Results 191 to 200 of about 45,578 (261)

Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The graphical abstract illustrates the action mechanisms through which PPE alleviates HUA by inhibiting XOD activity, and by suppressing the PI3K‐AKT signaling pathway to downregulate the expression of the urate reabsorption transporters URAT1 and GLUT9, thereby promoting renal UA excretion and attenuating renal injury.
Zeyu Yin, Shufei Liang, Gangao Yang, Pingping Guo, Chao Wang, Qingqing Han, Xinhua Song   +6 more
wiley   +1 more source

Seeing is believing: visualizing spatiotemporal lipophagic flux in vivo with the tfLiveDrop reporter mice. [PDF]

Autophagy Rep
Gong S, Yang C, Liu H.
europepmc   +1 more source

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6561-6575, August 2026.
ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu, Jiaying Ni, Qian Dou, Hang Su, Ziyi Zhang, Xiaojing Ma, Qing Dai, Jian Zhou   +7 more
wiley   +1 more source

High-Dose Voclosporin Protects Against Acute Kidney Injury via Regnase-2-Mediated NGAL MRNA Decay. [PDF]

Int J Mol Sci
Hasegawa K, Sakamaki Y, Tamaki M, Yamaguchi S, Miyakami S, Okinari C, Tada M, Otsuka M, Minato M, Wakino S.   +9 more
europepmc   +1 more source

Multi‐Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7416-7429, August 2026.
ABSTRACT Aims Empagliflozin is renoprotective in Type 2 diabetes mellitus (T2DM). Our primary aim was to assess empagliflozin's effect on glomerular filtration rate and renal vascular resistance using multiparametric MRI (MpMRI). Our secondary aim was to assess the impact of empagliflozin on additional MpMRI‐derived metrics including markers of tissue ...
Ruth P. Lim, Salma Qassin, Lucy McKenna, Emma Hornsey, Dominic Italiano, Leonid Churilov, Richard J. MacIsaac, Jas‐mine Seah, Elif I. Ekinci, The Austin EMPA‐MRI Study Group   +9 more
wiley   +1 more source

Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming. [PDF]

JCI Insight
Wanner N, Keller J, Liaukouskaya N, Andrieux G, Laufer SD, Rogg M, Bork T, Liang W, Braun F, Haas F, Wong MN, Puelles VG, Gies SE, Meyer C, Boerries M, Helmstädter M, Kretz O, Hild I, Metzger E, Schüle R, Bechtel-Walz W, Huber TB.   +21 more
europepmc   +1 more source

Renal function in African women receiving tenofovir disoproxil fumarate as pre‐exposure prophylaxis for HIV during pregnancy and postpartum: A postpartum safety analysis in the CAP016 randomized control trial

HIV Medicine, Volume 27, Issue 8, Page 1333-1343, August 2026.
Abstract Background The effect of tenofovir disoproxil fumarate (TDF) when used as pre‐exposure prophylaxis (PrEP) on renal function in pregnant and postpartum women is understudied. An open‐label clinical trial (CAP016 study) was designed to examine the safety of TDF‐PrEP use during pregnancy and breastfeeding.
Gaysheen Kistan, Tonya Esterhuizen, Megeshinee Naidoo, Alicia C. Desmond, Motshedisi Sebitloane, Dhayendre Moodley   +5 more
wiley   +1 more source

Tubules, Targets, and Translational Promise in Diabetic Kidney Disease. [PDF]

Kidney360
Martinez Leon V, Aggarwal S.
europepmc   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1268-1282, August 2026.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

Regulation of renal aquaporins: implications in tubular epithelial integrity. [PDF]

Biochem Soc Trans
Venkatesan V, Sørensen CM, Olesen ETB.
europepmc   +1 more source