Results 201 to 210 of about 45,578 (261)

Light Chain Crystalline Proximal Tubulopathy and Podocytopathy With Staining for Both Light and Heavy Chain Immunoglobulin

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT A 69‐year‐old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA‐κ type.
Seoyoung Choi, Kyung Chul Moon
wiley   +1 more source

Heterogeneity in lysosomal dynamics and metabolic functions along the kidney proximal tubule. [PDF]

Nat Commun
Kaminska M, Sakhi IB, Jankovic N, Polesel M, Hall AM.   +4 more
europepmc   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source

Irisin-Driven AMPK-PGC-1α Activation Underlies the Renoprotective Effects of Swimming Exercise in Obesity-Induced Kidney Injury. [PDF]

Biomolecules
Hanafy SM, Zakaria SS, Jumaa MI, Al-Dhelaan RA, Yousef EM.   +4 more
europepmc   +1 more source

Evidence that S‐phase kinase associated protein 2 (SKP2) is ubiquitinated and degraded via a Rho‐related BTB domain containing 1 (RhoBTB1) and Cullin‐3 mechanism in placenta

Physiological Reports, Volume 14, Issue 15, August 2026.
Graphical representation of mechanism by which RhoBTB1 regulates SKP2. Abstract Rho related BTB domain containing 1 (RhoBTB1) is highly expressed in placenta and functions to deliver protein targets to the Cullin‐3 (CUL3) E3 ubiquitin ligase where they are targeted for ubiquitination and degradation.
Alina L. Tvina, M. Christine Livergood, Gaurav Kumar, Valerie W. Hole, Megan A. Opichka, Luisangeli Muniz Irizarry, Ko‐Ting Lu, Kelsey K. Wackman, Justin L. Grobe, Pablo Nakagawa, Jennifer J. McIntosh, Curt D. Sigmund   +11 more
wiley   +1 more source

Mechanism of Sodium-Glucose Cotransporter-2 Inhibitors for Uricosuria. [PDF]

Electrolyte Blood Press
Bae E.
europepmc   +1 more source

Ubiquitination‐Related Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The Graphical Abstract demonstrates our research approach. Use GEO database to screen differentially expressed genes (DEGs), and weighted gene co expression network analysis (WGCNA) to identify ubiquitination related gene modules. The LASSO logistic regression and support vector machine recursive feature elimination (SVM‐RFE) algorithm is used to ...
Ting Dong, Miao Hu, Haibo Yu, Ling Zhou, Qing Qiao   +4 more
wiley   +1 more source

Proximity Labeling Reveals How Lrp2 Interacts with the Endocytic Machine. [PDF]

J Proteome Res
Shen TH, Beenken A, Erdjument-Bromage H, Weisz OA, Ghotra A, Kushner JS, Sturley RE, Kahn A, Kronenberg L, Rahmani G, Nesanir K, High FA, Donahoe PK, Barasch J, Neubert TA.   +14 more
europepmc   +1 more source

SGLT2 Inhibition Attenuates Renal Tubular Senescence by Suppressing CTRP1‐Mediated Glucotoxic Stress in Diabetic Kidney Disease

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Hyperglycemia upregulates CTRP1 and SGLT2 in renal tubular cells, promoting glucose influx, CTRP1‐mediated glucotoxic stress, and tubular senescence in diabetic kidney disease. In the experimental model, SGLT2 inhibition with dapagliflozin was associated with reduced glucose uptake, attenuation of tubular senescence, suppression of CTRP1‐related ...
Lina Gu, Buhui Liu, Lei Zhang, Jing Zhao, Weiming He, Hong Lang, Wei Sun   +6 more
wiley   +1 more source

Galectin-3 in AKI: Pathogenic Target, Diagnostic Biomarker, or Both? [PDF]

Int J Biol Sci
Gui Y, Zhou D.
europepmc   +1 more source