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AQP1 expression in the proximal tubule of diabetic rat kidney [PDF]
Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown ...
Alicia E Damiano
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SEM of the proximal tubule of the adult rabbit kidney
The Anatomical Record, 1978AbstractThe present study utilizes the scanning electron microscope (SEM) to reveal the surface morphology of proximal tubular cells and the parietal cells of Bowman's capsule of the adult rabbit nephron. To facilitate the examination of the basal surface of these cells, proximal tubules were dissected free and treated with collagenase to remove the ...
A P, Evan, D A, Hay, W G, Dail
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Oxalate transport by proximal tubule of the rabbit kidney
American Journal of Physiology-Renal Physiology, 1982Oxalate transport was examined in isolated perfused segments of the proximal tubule of the rabbit. When oxalate was present in a concentration of 10(-5) M in the bathing and perfusing solutions, there was a net secretory flux of oxalate of 36.4 +/- 1.4, 34.7 +/- 4.3, and 20.7 +/- 2.8 x 10(-15) mol . min-1 .
H O, Senekjian, E J, Weinman
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Phagocytosis of erythrocytes by the proximal tubule of the rat kidney
Cell and Tissue Research, 1982Morphological examination of kidney biopsies from patients with glomerulonephritis and hematuria has revealed the presence of erythrocytes within epithelial cells of the proximal tubule. This observation suggested that the proximal tubule might be capable of phagocytizing morphologically intact erythrocytes. To examine this possibility small quantities
K M, Madsen, C W, Applegate, C C, Tisher
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Role of Proximal Tubules in the Pathogenesis of Kidney Disease
2011The proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located. Under normal circumstances, more than two thirds of filtered salt and water, and all filtered bicarbonate is ...
Nazih, Nakhoul, Vecihi, Batuman
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Metabolic heterogeneity of the proximal and distal kidney tubules
Life Sciences, 1983Proximal and distal tubule suspensions were prepared from kidneys of Sprague-Dawley rats by an isolation procedure on a Percoll gradient. The marker enzymes alkaline phosphatase (brush border) and hexokinase (cytoplasmic) as well as p-aminohippurate transport capacity, gluconeogenic activity and electron microscopy were used to characterize the two ...
C, Cojocel +4 more
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Hemoglobin absorption in the proximal tubules of the kidney in the rabbit
Journal of Ultrastructure Research, 1967Relatively small quantities of hemoglobin, 1.5 mg per cubic centimeter of blood, were injected intravenously into rabbits, and ultrastructural changes in the proximal tubular epithelial cells of the kidney were followed over a 24-hour period. These experiments and prior experiments have shown that the hemoglobin is absorbed by proximal tubular cells of
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The effect of sex hormones on the proximal tubules in the rat kidney
Cell and Tissue Research, 1978The three segments (S1, S2, S3) of the proximal tubule of the rat kidney were investigated, with special reference to lysosomes, after castration, estradiol application, and at the end of pregnancy. Especially in S1 and S2 castration induces an increase of cellular autophagy.
T H, Schiebler, K G, Danner
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Volume regulation in the early proximal tubule of theNecturus kidney
The Journal of Membrane Biology, 1987The ability of early proximal tubule cells of the Necturus kidney to regulate volume was evaluated using light microscopy, video analysis and conventional microelectrodes. Necturus proximal tubule cells regulate volume in both hyper- and hyposmotic solutions.
A G, Lopes, W B, Guggino
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Urate Transport in the Proximal Tubule of Human Kidney
1991Urate is transported bidirectionally by the renal proximal tubule of mammals. The direction of the net flux is, however, highly species dependent, so that some mammals are urate “reabsorbers” while others are urate “secreters” (Roch-Ramel and Weiner, 1980).
Werner D, Guisan B, Roch-Ramel F
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