Results 191 to 200 of about 85,860 (310)

Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change

BioEssays, Volume 47, Issue 6, June 2025.
Cell shape changes underlie animal development, physiology, and disease. The cell surface is mechanosensitive to the microenvironment and cytoskeleton activities, which generate plasma membrane topographies recognized and affected by Arp2/3 actin network induction pathways to remodel cell shape during immune cell migration, neural progenitor cell ...
Tony J. C. Harris
wiley   +1 more source

Suggestions for attenuation of renal ischemia reperfusion injury based on mechanisms involved in epithelial cells damages [PDF]

Journal of Nephropharmacology, 2015
Tavafi Majid
doaj  

Autophagic stagnation: a key mechanism in kidney disease progression linked to aging and obesity. [PDF]

Clin Exp Nephrol
Yamamoto T.
europepmc   +1 more source

The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice

Brain and Behavior, Volume 15, Issue 6, June 2025.
The small molecules RepSox and TCP were investigated for their geroprotective effects in aging C3H mice through intraperitoneal administration. Treatment resulted in improved neurological markers and physical parameters in older mice (16‐20 months), while younger treated mice (10‐13 months) showed increased maximum lifespan compared to controls.
Maria Vedunova, Olga Borysova, Elena Mitroshina, Ivan Morgunov, Alexander Fedintsev, Alexey Moskalev   +5 more
wiley   +1 more source

Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
ISG15 is highly expressed in both DKD mice and renal tubular epithelial cell cultured in HG condition. ISG15 promotes DKD pyroptosis via NLRP3–CASP1–GSDMD axis. ISG15–mtDNA–STING emerges as a critical hub that integrates the processes of pyroptosis .
Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang   +8 more
wiley   +1 more source

Tubular damage and SGLT2 expression in a patient with Beni-koji tablet-associated acute kidney injury and Fanconi syndrome. [PDF]

CEN Case Rep
Kamada A, Hirose T, Hashimoto H, Konya Y, Sato F, Ishiyama K, Joh K, Yumura W, Mori T.   +8 more
europepmc   +1 more source

Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice. [PDF]

Sci Rep
Cwiek A, Dailey RK, Kameshwar AKS, Suzuki M, Isaac J, deRonde K, Conaway M, Bennett KM, Baldelomar EJ, Li T, Wu T, Hoch MR, Chavkin NW, Walker PD, Hirschi KK, Reidy KJ, Charlton JR.   +16 more
europepmc   +1 more source

Randomized trial to assess worsening renal function by adding dapagliflozin for acute decompensated heart failure

ESC Heart Failure, Volume 12, Issue 3, Page 2023-2033, June 2025.
Abstract Aims Dapagliflozin (DAPA), a sodium‐glucose co‐transporter 2 inhibitor, has been shown to reduce cardiovascular mortality among patients with chronic heart failure. We aimed to evaluate the impact on a worsening renal function (WRF) by adding DAPA as compared to standard decongestive therapy with loop diuretics alone.
Shodai Kawanami, Yasuyuki Egami, Masaru Abe, Mizuki Osuga, Hiroaki Nohara, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga‐Lee, Masamichi Yano, Masami Nishino   +11 more
wiley   +1 more source

NAD+ prevents chronic kidney disease by activating renal tubular metabolism. [PDF]

JCI Insight
Jones BA, Gisch DL, Myakala K, Sadiq A, Cheng YH, Taranenko E, Panov J, Korolowicz K, Melo Ferreira R, Yang X, Santo BA, Allen KC, Yoshida T, Wang XX, Rosenberg AZ, Jain S, Eadon MT, Levi M.   +17 more
europepmc   +1 more source

Anti‐Hyperlipidemic and Anti‐Atherogenic Effect of Citrus Peel Pectin Against Cholesterol and Cholic Acid Induced Hyperlipidemia in Sprague Dawley Rats

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
ABSTRACT This study was designed to explore the anti‐hyperlipidemic and anti‐atherogenic effects of citrus peel‐derived pectin. A total of 70 Sprague Dawley rats were categorized into 7 groups with 10 rats in each group. Hyperlipidemia was induced in all groups by adding cholesterol (1.5%) and cholic acid (0.5%) to the normal diet for 15 days.
Hina Rasheed, Ammar B. Altemimi, Roshina Rabail, Sidra Tul Muntaha, Allah Rakha, Usman Haider, Fareha Rasheed, Maham Shehzad, Amin Mousavi Khaneghah, Gholamreza Abdi, Rana Muhammad Aadil   +10 more
wiley   +1 more source