Results 101 to 110 of about 82,000 (295)

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

A Novel Self-aligned and Maskless Process for Formation of Highly Uniform Arrays of Nanoholes and Nanopillars

Nanoscale Research Letters, 2008
Fabrication of a large area of periodic structures with deep sub-wavelength features is required in many applications such as solar cells, photonic crystals, and artificial kidneys.
Wu Wei, Dey Dibyendu, Memis Omer, Katsnelson Alex, Mohseni Hooman   +4 more
doaj   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

Assessing Change in Stone Burden on Baseline and Follow-Up CT: Radiologist and Radiomics Evaluations

Journal of Imaging
This retrospective diagnostic accuracy study compared radiologist-based qualitative assessments and radiomics-based analyses with an automated artificial intelligence (AI)–based volumetric approach for evaluating changes in kidney stone burden on follow ...
Parisa Kaviani, Matthias F. Froelich, Bernardo Bizzo, Andrew Primak, Giridhar Dasegowda, Emiliano Garza-Frias, Lina Karout, Anushree Burade, Seyedehelaheh Hosseini, Javier Eduardo Contreras Yametti, Keith Dreyer, Sanjay Saini, Mannudeep Kalra   +12 more
doaj   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

Preoperative and postoperative imaging as a surgical strategy and feedback on abdominal aortic aneurysm with horseshoe kidney: Case report

SAGE Open Medical Case Reports
A 77-year-old man was diagnosed with an infrarenal abdominal aortic aneurysm coexisting with a horseshoe kidney detected on a computed tomography (CT) scan.
Shizuko Iwasa, Takeshi Katsube, Azumi Hamasaki   +2 more
doaj   +1 more source

Lactococcus garvieae as a Novel Pathogen in Cultured Pufferfish (Takifugu obscurus) in China

Fishes
In October 2023, a disease outbreak in pufferfish (Takifugu obscurus) farms in Zhongshan City, Guangdong, China, caused high mortality. Diseased fish (mean length: 15 ± 1 cm) exhibited swimming disorders, fin rot, hemorrhage, and an enlarged spleen ...
Ruilong Xu, Zhongning He, Yiyang Deng, Yihao Cen, Zequan Mo, Xueming Dan, Yanwei Li   +6 more
doaj   +1 more source

Organ Transplantation in Medical and Legal Perspectives [PDF]

, 1967
Stickel, Delford L.
core   +2 more sources