Results 81 to 90 of about 82,000 (295)
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Leptospira infection among pigs in southern Vietnam [PDF]
, 2002 Leptospirosis is a bacterial disease that in pigs primarily causes reproductive disturbances. The disease is a zoonosis, i.e. it can be transmitted between animals and humans.
Boqvist, Sofia
core
Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis
Advanced Science, EarlyView.This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu +4 more
wiley +1 more source
Biological data from post mortem analysis of otters in Hungary [PDF]
, 2008 In this paper we examined the characteristics of reproduction parameters, stomach content and inner organ weights on carcasses (male, n=67, female n=57, unknown n=3) of otters (Lutra lutra) collected in Hungary between 1999 and 2006.
Lanszki, József +3 more
core
Paving the Way to Elucidate Hg's Role in Tumorigenesis
Advanced Science, EarlyView.Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li +10 more
wiley +1 more source
Doing, Feeling, Meaning And Explaining [PDF]
, 2011 It is “easy” to explain doing, “hard” to explain feeling. Turing has set the agenda for the easy explanation (though it will be a long time coming). I will try to explain why and how explaining feeling will not only be hard, but impossible.
Harnad, Stevan
core
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Pediatric Type II Diabetes Mellitus: Examining the Upward Trend [PDF]
, 2018 In recent years, there has been a significant increase in pediatric onset of type II diabetes. This paper will examine elements contributing to this trend.
Foering, Allison
core +1 more source
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source