Results 91 to 100 of about 82,000 (295)

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

AI generated annotations for Breast, Brain, Liver, Lungs, and Prostate cancer collections in the National Cancer Institute Imaging Data Commons

Scientific Data
The Artificial Intelligence in Medical Imaging (AIMI) initiative aims to enhance the National Cancer Institute’s (NCI) Image Data Commons (IDC) by releasing fully reproducible nnU-Net models, along with AI-assisted segmentation for cancer radiology ...
Gowtham Krishnan Murugesan, Diana McCrumb, Rahul Soni, Jithendra Kumar, Leonard Nuernberg, Linmin Pei, Ulrike Wagner, Sutton Granger, Andrey Y. Fedorov, Stephen Moore, Jeff Van Oss   +10 more
doaj   +1 more source

Kidney-inspired algorithm with reduced functionality treatment for classification and time series prediction.

PLoS ONE, 2019
Optimization of an artificial neural network model through the use of optimization algorithms is the common method employed to search for an optimum solution for a broad variety of real-world problems.
Najmeh Sadat Jaddi, Salwani Abdullah
doaj   +1 more source

Tissue engineering and stem cell therapy in pediatric urology

Journal of Indian Association of Pediatric Surgeons, 2019
The rapidly expanding field of tissue engineering along with stem cell therapy has a promising future in pediatric urological conditions. The initial struggle seemed difficult in renal regeneration but a functional biounit has been developed.
Shilpa Sharma, Devendra K Gupta
doaj   +1 more source

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. [PDF]

, 2019
Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1-3 (HNP1-3) are the most abundant neutrophil granule proteins but their neutrophil content varies because ...
Chen, QiXing, Fang, XiangMing, Fu, WeiTao, Ganz, Tomas, Han, Feng, Hou, JinChao, Hou, TingJun, Linzmeier, Rose, Nemeth, Elizabeta, Shu, Qiang, Yang, Yang, Yin, YiXuan, Zeng, CongLi   +12 more
core   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Influence of Amino Acids on Calcium Oxalate Precipitation in Systems of Different Chemical Complexity

Crystals
The mechanisms and conditions under which urinary stones, pathological biominerals in the kidneys and bladder, are formed have not yet been fully clarified.
Anamarija Stanković, Nives Matijaković Mlinarić, Jasminka Kontrec, Branka Njegić Džakula, Daniel M. Lyons, Berislav Marković, Damir Kralj   +6 more
doaj   +1 more source

Surgical technique of orthotopic liver transplantation [PDF]

, 1988
Athough significant strides have been made in the surgical technique of orthotopic liver transplantation, numerous problems and nuisances are still encountered. Further surgical refinements will certainly evolve.
Bowman, J, Kahn, D, Makowka, L, Mieles, L, Sher, L, Starzl, TE, Stieber, AC, Wallis Marsh, J   +7 more
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source