Results 11 to 20 of about 71,763 (262)

Nascent competition and killer acquisitions in digital markets: a decade of acquisitions by Big Tech

Journal of Antitrust Enforcement, 2023
Abstract Acquisitions in digital markets by dominant companies such as Google, Apple, Facebook, Amazon, and Microsoft (GAFAM) raise, among others, concerns related to the elimination of nascent competition. While demands for merger control reforms in this segment are proliferating, there are still important controversies and ...
Thales de Melo e Lemos, Guilherme Mendes Resende   +1 more
openaire   +1 more source

Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis. [PDF]

PLoS ONE, 2014
Natural killer (NK) cells have the capacity to target tumors and are ideal candidates for immunotherapy. Viral vectors have been used to genetically modify in vitro expanded NK cells to express chimeric antigen receptors (CARs), which confer cytotoxicity
Fu-Nan Cho, Tsung-Hsien Chang, Chih-Wen Shu, Ming-Chin Ko, Shuen-Kuei Liao, Kang-Hsi Wu, Ming-Sun Yu, Shyh-Jer Lin, Ying-Chung Hong, Chien-Hsun Chen, Chien-Hui Hung, Yu-Hsiang Chang   +11 more
doaj   +1 more source

High-throughput mass cytometry staining for deep phenotyping of human natural killer cells

STAR Protocols, 2022
Summary: This protocol details the step-by-step procedure for in-depth immune phenotyping of peripheral blood natural killer (NK) cells from clinical samples by mass cytometry.
Amira Ben Amara, Marie-Sarah Rouviere, Stéphane Fattori, Julia Wlosik, Emilie Gregori, Nicolas Boucherit, Pierre-Louis Bernard, Jacques A. Nunès, Norbert Vey, Herve Luche, Laurent Gorvel, Daniel Olive, Anne-Sophie Chretien   +12 more
doaj   +1 more source

Changes in Natural Killer cell activation and function during primary HIV-1 Infection. [PDF]

PLoS ONE, 2013
Recent reports suggest that Natural Killer (NK) cells may modulate pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We dissected this bi-directional relationship to understand how HIV impacts NK-cell responses during ...
Vivek Naranbhai, Marcus Altfeld, Salim S Abdool Karim, Thumbi Ndung'u, Quarraisha Abdool Karim, William H Carr   +5 more
doaj   +1 more source

Effects of a natural nutritional supplement on immune cell infiltration and immune gene expression in exercise-induced injury

Frontiers in Nutrition, 2022
Inflammatory immune response plays a key role in exercise-induced injury and healing; however, the relevant regulatory mechanisms of immune infiltration in exercise-induced injuries remain less studied. In the present study, a highly efficient system for
Feng Jiang, Rongfeng Yang, Diya Xue, Rong Li, Meiling Tan, Zhicong Zeng, Luhua Xu, Linling Liu, Yinzhi Song, Fengxia Lin   +9 more
doaj   +1 more source

4‐1BB and cytokines trigger human NK, γδ T, and CD8+ T cell proliferation and activation, but are not required for their effector functions

Immunity, Inflammation and Disease, 2023
Introduction This study was designed to compare the costimulatory molecules and cytokines required to trigger the proliferation and activation of natural killer (NK), γδ T, and CD8+ T cells, and gain in‐depth insight into the mechanisms shifting ...
Laurent Vidard
doaj   +1 more source

Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children

Haematologica, 2010
Background Natural killer cells have been demonstrated to exert remarkable graft-versus-leukemia effects after haploidentical transplantation. Acquisition of both, inhibiting and activating, receptors on developing natural killer cells is an important ...
Matthias M. Pfeiffer, Tobias Feuchtinger, Heiko-Manuel Teltschik, Michael Schumm, Ingo Müller, Rupert Handgretinger, Peter Lang   +6 more
doaj   +1 more source

CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques

Cell Reports, 2018
Summary: Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg)
Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, R. Keith Reeves   +8 more
doaj   +1 more source

NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation

iScience, 2023
Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development ...
Sabrina Giampaolo, Cristina M. Chiarolla, Konrad Knöpper, Martin Vaeth, Matthias Klein, Azeem Muhammad, Tobias Bopp, Friederike Berberich-Siebelt, Amiya K. Patra, Edgar Serfling, Stefan Klein-Hessling   +10 more
doaj   +1 more source

Geographic and temporal patterns of non-lethal attacks on humpback whales by killer whales in the eastern South Pacific and the Antarctic Peninsula

Endangered Species Research, 2018
The role and impact of killer whales Orcinus orca as predators of baleen whales has been emphasized by studies of humpback whales Megaptera novaeangliae.
Capella, JJ, Félix, F, Flórez-González, L, Gibbons, J, Haase, B, Guzman, HM   +5 more
doaj   +1 more source