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Natural Killer Cells and Cancer
2003Natural killer (NK) cells are lymphocytes that were first identified for their ability to kill tumor cells without deliberate immunization or activation. Subsequently, they were also found to be able to kill cells that are infected with certain viruses and to attack preferentially cells that lack expression of major histocompatibility complex (MHC ...
Jun, Wu, Lewis L, Lanier
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Natural killer cells and their receptors
Transplant Immunology, 2002Natural killer (NK) cells have been known for a long time to be a very important component of the innate immune system. However, it is only during the last 10 years that knowledge of their receptors has emerged. Described in the present review are those receptor families killer inhibitory receptor (KIR) (belonging to the immunoglobulin superfamily ...
Derek, Middleton +2 more
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Natural killer cells and reproduction
Trends in Immunology, 2002Abstract The Cambridge Immunology and Reproductive Immunology Groups of the British Society for Immunology held a meeting on NK Cells and Reproduction at King's College, Cambridge, UK, on 2–4 April, 2002.
Ashley, Moffett-King +4 more
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Natural killer cells in cancer
Seminars in Cancer Biology, 2006Publisher Summary Integrated with other immune cells, natural killer (NK) cells contribute to host anti-microbial and anti- tumor immunity. The provision of early defence mechanisms against viral infections, particularly herpes viruses, is perhaps the most important clinical effect by NK cells, but it was their cytotoxic potency against tumor cells ...
Petter, Höglund, Eva, Klein
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Natural killer cells and pregnancy
Nature Reviews Immunology, 2002The fetus is considered to be an allograft that, paradoxically, survives pregnancy despite the laws of classical transplantation immunology. There is no direct contact of the mother with the embryo, only with the extraembryonic placenta as it implants in the uterus.
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Natural Killer Cells for Osteosarcoma
2014Natural killer (NK) cells are lymphocytes of the innate immune system that have the ability to recognize malignant cells through detection of a variety of cell-surface indicators of stress and danger. Once activated through such recognition, NK cells release cytokines and induce target cell lysis through a variety of mechanisms.
Nidale, Tarek, Dean A, Lee
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Immunoregulation and natural killer cells
Molecular Immunology, 1982Natural killer (NK) cells have a cytotoxic activity against a variety of tumor cells and also against some microorganisms or cells infected by microbial agents. They may thereby serve as important effector cells in host resistance against disease. NK cells are present in virtually all individuals, can be activated rapidly by a wide range of stimuli ...
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Current Opinion in Immunology, 1997
The specificity in the recognition of hematopoietic target cells by natural killer cells is primarily provided by inhibitory receptors and several such receptors have been identified in the past year. Surprisingly, the recognition of MHC class I molecules by inhibitory receptors on human natural killer cells involves two different types of receptors ...
E O, Long, N, Wagtmann
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The specificity in the recognition of hematopoietic target cells by natural killer cells is primarily provided by inhibitory receptors and several such receptors have been identified in the past year. Surprisingly, the recognition of MHC class I molecules by inhibitory receptors on human natural killer cells involves two different types of receptors ...
E O, Long, N, Wagtmann
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Current Hematologic Malignancy Reports, 2009
The natural killer (NK)-cell neoplasms are rare, representing less than 1% of non-Hodgkin lymphoma, except in Asia and Latin America, where they represent 3% to 6%. NK-cell neoplasms include immature acute leukemias; a blastic NK-cell lymphoma, which is obsolete because of its plasmacytoid dendritic-cell origin; and mature NK neoplasms, comprising ...
John P, Greer, Claudio A, Mosse
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The natural killer (NK)-cell neoplasms are rare, representing less than 1% of non-Hodgkin lymphoma, except in Asia and Latin America, where they represent 3% to 6%. NK-cell neoplasms include immature acute leukemias; a blastic NK-cell lymphoma, which is obsolete because of its plasmacytoid dendritic-cell origin; and mature NK neoplasms, comprising ...
John P, Greer, Claudio A, Mosse
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Improving natural killer cells
Cytotherapy, 2008Donor lymphocyte infusions after stem cell transplantation have taught the cancer community that human immune cells have the potential power to control growth of and even eliminate a malignant clone. Although infusion of allogeneic T lymphocytes after stem cell transplantation has become part of the treatment algorithm, either to prevent or treat ...
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