Results 151 to 160 of about 2,580,938 (299)

DeepKinome: quantitative prediction of kinase binding affinity by a compound using deep learning based regression model. [PDF]

Front Mol Biosci
Lee Y, Eun J, Lee J, Nam S.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Discovery of N8: a novel IKKε inhibitor with potent anticancer activity via cytotoxicity, migration suppression, and autophagy modulation. [PDF]

J Enzyme Inhib Med Chem
Ye W, Zheng S, Xie H, Zhou X, Xu J, Luo Q, Huang Y, Li J, Diao J, Luo X, Zhu Q, Liu G.   +11 more
europepmc   +1 more source

Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase [PDF]

, 2000
Peter F. Flynn, Xiangyi Gan, Adele Casamassima, Peter J. Parker   +3 more
openalex   +1 more source

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Cell, 1995
C. Marshall
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Spinning-Induced Exertional Rhabdomyolysis Without Acute Kidney Injury. [PDF]

Clin Case Rep
Gutierrez YV, Shaju R, Sepulveda A, Rivera J, Ahmad A.   +4 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Phosphorylation of a conserved aspartate in the catalytic site of eukaryotic elongation factor 2 kinase. [PDF]

Protein Sci
Piserchio A, Isiorho EA, Abzalimov R, Dalby KN, Ghose R.   +4 more
europepmc   +1 more source

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts [PDF]

, 2000
Lars‐Oliver Klotz, Stefan M. Schieke, Helmut Sies, Nikki J. Holbrook   +3 more
openalex   +1 more source