Results 211 to 220 of about 2,580,938 (299)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence. [PDF]

Rheumatology (Oxford)
Nolan A, Foulkes DM, Fairweather EE, Alarcon MF, Linford C, Sellin A, McLaren Z, Eyers PA, Wright HL.   +8 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities. [PDF]

Cancers (Basel)
Vrachas D, Kosma E, Giannopoulou AI, Margoni A, Gargalionis AN, El-Habr EA, Piperi C, Adamopoulos C.   +7 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance. [PDF]

Endocr Connect
Zhao C, Zhang Z, Li R, Geng X.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Editorial: Cell Signaling in Host–Pathogen Interactions: The Host Point of View

Frontiers in Immunology, 2018
Diana Bahia, Abbhay R. Satoskar, Abbhay R. Satoskar, Olivier Dussurget, Olivier Dussurget, Olivier Dussurget, Olivier Dussurget   +6 more
doaj   +1 more source

Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity. [PDF]

Biochem J
Horne CR, Wang T, Young SN, Dite TA, Nyvall HG, Suresh S, Davies KA, Gonzalez Castro A, Vaibhav V, Mather LJ, Dagley LF, Belousoff MJ, Manning G, Means AR, Burke JE, Petersen J, Scott JW, Murphy JM.   +17 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source