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Cardiotoxicity of small-molecule kinase inhibitors in cancer therapy. [PDF]
Zhu S+9 more
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NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex. [PDF]
Roig J.
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Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson’s Disease
Pratuseviciute N+6 more
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MAP kinase kinase kinases and innate immunity
Trends in Immunology, 2006Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Sören Beinke+2 more
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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
Frontiers in Bioscience, 2008The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria+2 more
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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
Current Opinion in Genetics & Development, 1994Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
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Kinase dysfunction and kinase inhibitors
Veterinary Dermatology, 2013With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
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