Results 221 to 230 of about 4,906,436 (344)

Macrocyclic Inhibitors of ERK2 Kinase [PDF]

ACS Medicinal Chemistry Letters, 2016
openaire   +2 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Three Janus kinase inhibitors in ulcerative colitis: is upadacitinib taking the lead? [PDF]

Intest Res
Jung YS.
europepmc   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Selective Janus kinase inhibitors exhibit different effects in murine immune aplastic anemia. [PDF]

Hemasphere
Durrani J, Feng X, Wu Z, Gao S, Manley AL, Wu L, Glass J, Patel BA, Chen J, Young NS, Groarke EM.   +10 more
europepmc   +1 more source

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Bruton tyrosine kinase inhibitors in combination with chemoimmunotherapy is an effective treatment for patients with Richter's syndrome. [PDF]

Leuk Res Rep
Meier T, Huynh G, Ayala E, Tun HW, Iqbal M.   +4 more
europepmc   +1 more source

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

Experimental parasitology, 2017
W. V. Van Voorhis, J. S. Doggett, M. Parsons, Matthew A. Hulverson, Ryan Choi, S. Arnold, M. Riggs, A. Hemphill, D. Howe, R. Mealey, Audrey O. T. Lau, E. Merritt, Dustin J Maly, Erkang Fan, K. Ojo   +14 more
semanticscholar   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

Bibliometric analysis and recent trends on tyrosine kinase inhibitors in leukemia. [PDF]

Discov Oncol
Cheng J, Fang Y, Dong J, Zhang X, Yuan Y, Dang X.   +5 more
europepmc   +1 more source