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A meta-analysis of the efficacy and safety of Janus kinase inhibitors in patients with ulcerative colitis. [PDF]
Medicine (Baltimore)Yang Q, Yan Y.
europepmc +1 more source
, 2017 The strategy of applying kinase inhibitors as effective therapeutic agents has achieved unparalleled success in the past decade, while it is still a daunting challenge to develop kinase inhibitors with desirable selectivity among different kinase ...
CAPALDI CARMELIDA +3 more
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Current Medicinal Chemistry, 2015
The limitations of many mono-kinase inhibitors can be overcome by agents with multi-target action. An important advantage of targeting more than one kinase, is an increase in potency, due to the synergistic effect. Moreover, this approach can reduce the possibility of developing drug resistance.
GARUTI, LAURA +2 more
openaire +3 more sources
The limitations of many mono-kinase inhibitors can be overcome by agents with multi-target action. An important advantage of targeting more than one kinase, is an increase in potency, due to the synergistic effect. Moreover, this approach can reduce the possibility of developing drug resistance.
GARUTI, LAURA +2 more
openaire +3 more sources
Current Cancer Drug Targets, 2010
Over the last ten years, several new and therapeutically relevant cancer drugs targeting tyrosine kinases signaling pathways have been developed. Tyrosine kinase inhibitors (TKIs) are a pharmaceutical class of small molecules, orally available, well-tolerated, worldwide approved drugs for the treatment of several neoplasms, including lung, breast ...
NATOLI, Clara +5 more
openaire +3 more sources
Over the last ten years, several new and therapeutically relevant cancer drugs targeting tyrosine kinases signaling pathways have been developed. Tyrosine kinase inhibitors (TKIs) are a pharmaceutical class of small molecules, orally available, well-tolerated, worldwide approved drugs for the treatment of several neoplasms, including lung, breast ...
NATOLI, Clara +5 more
openaire +3 more sources
Kinase dysfunction and kinase inhibitors
Veterinary Dermatology, 2013With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
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Small Molecule Kinase Inhibitor Drugs (1995–2021): Medical Indication, Pharmacology, and Synthesis
Journal of Medicinal Chemistry, 2022Álvaro Lorente-Macías +2 more
exaly
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light
Angewandte Chemie - International Edition, 2021Stefan Knapp +2 more
exaly
Angiogenesis Inhibitors: Current Strategies and Future Prospects†‡
Ca-A Cancer Journal for Clinicians, 2010Kristina M Cook, W D Figg
exaly