Results 61 to 70 of about 147,757 (263)

Metabolic Kinases Moonlighting as Protein Kinases [PDF]

Trends in Biochemical Sciences, 2018
Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin, Lu, Tony, Hunter
openaire   +2 more sources

Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

Frontiers in Chemistry
IntroductionA novel series of quinolin‐2(1H)‐one derivative was rationally designed, synthesized, and characterized as potential dual inhibitors of EGFR and HER-2.MethodsStructural elucidation was achieved through IR, NMR, mass spectrometry, elemental ...
Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Martin Nieger, Stefan Bräse, Bahaa G. M. Youssif, Hendawy N. Tawfeek, Hendawy N. Tawfeek   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Schematic illustration of hit kinases/phosphatase and inhibitors targeting the kinases.

, 2020
Schematic illustration of hit kinases/phosphatase and inhibitors targeting the kinases.
Heikki Kuusanmäki (8649435), Elina Parri (4336678), Arjan J. van Adrichem (3876706), Krister Wennerberg (458006), Meri Kaustio (323294)   +4 more
core   +1 more source

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia [PDF]

, 2015
Deletion of exon 9 from Cullin-3 (CUL3, residues 403-459: CUL3Δ403-459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt).
Nichola L Figg, Thimo Kurz, Johnson, Clare, Yasmin, Nicola Wood, Al Maskari, Raya S, Frances‐Rose Schumacher, Kevin M O'Shaughnessy, James T Ferryman, Figg, Nichola L, Keith Siew, Knebel, Axel, Axel Knebel, Iris Hardege, Wood, Nicola, Figg, Nichola L., Sarah E Cleary, Ferryman, James T., O'Shaughnessy, Kevin M., Enchev, Radoslav, Schumacher, Frances-Rose, Cleary, Sarah E, Hardege, Iris, Al Maskari, Raya S., Kurz, Thimo, Siew, Keith, Cleary, Sarah E., Radoslav Enchev, Ferryman, James T, Clare Johnson, Jinwei Zhang, O'Shaughnessy, Kevin M, Zhang, Jinwei, Raya S Al Maskari, Yasmin, [No Value], Figg NL, Zhang J, Schumacher FR, O'Shaughnessy KM, Kurz T, Al Maskari RS, Hardege I, Knebel A, Cleary SE, Siew K, Ferryman JT, Johnson C, Enchev R, Wood N   +48 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Integrin Adhesion: When Is a Kinase a Kinase? [PDF]

Current Biology, 2002
Recent genetic studies in the worm Caenorhabditis elegans and fruitfly Drosophila have revealed the essential role integrin-linked kinase plays in integrin adhesion - but it apparently acts in this role as an adaptor rather than a kinase.
Zervas, Christos G, Brown, Nicholas H
openaire   +2 more sources

MicroRNAs hsa-miR-618 and hsa-miR-297 Might Modulate the Pleiotropic Effects Exerted by Statins in Endothelial Cells Through the Inhibition of ROCK2 Kinase: in-silico Approach

Frontiers in Cardiovascular Medicine, 2021
Several studies show that statin therapy improves endothelial function by cholesterol-independent mechanisms called “pleiotropic effects.” These are due to the inhibition of the RhoA/ROCK kinase pathway, its inhibition being an attractive ...
Karla Leal, Kathleen Saavedra, Camilo Rebolledo, Luis A. Salazar   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source