Results 71 to 80 of about 147,757 (263)

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]

, 2009
Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana, Ana Tomasovic, Tikkanen Ritva, Fernow Inga, Inga Fernow, Siehoff-Icking, Ann, Fernow, Inga Susanne, Tikkanen, Ritva, Ann Siehoff-Icking, Tomasovic Ana, Siehoff-Icking Ann, Ritva Tikkanen   +11 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

VEGF Receptor Tyrosine Kinases

, 2017
Vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are key regulators of vascular development in vertebrates. Their activation is regulated through a family of secreted glycoproteins, the vascular endothelial growth factors (VEGFs ...
Konstantin Gaengel, Gaengel, Konstantin,, Muhl, L,, Muhl, Lars,, Lars Muhl, Gaengel, K, Alberto Álvarez-Aznar, Alvarez, Alberto,, Alvarez-Aznar, A   +8 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks

Frontiers in Plant Science, 2020
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan, Lixia Pan, Ive De Smet, Ive De Smet   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

Molecular Neurodegeneration, 2011
Background Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood.
Judge Monique, Hornbeck Lisa, Potter Huntington, Padmanabhan Jaya   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Bacterial Protein-Tyrosine Kinases [PDF]

, 2010
Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way.
Kobir, Ahasanul, Jers, Carsten, Mijakovic, Ivan, Ahasanul Kobir, Shi, Lei, Ivan Mijakovic, Lei Shi, Carsten Jers   +7 more
core   +1 more source

wild-type kinases

, 2023
wild-type ...
Xiyu Chen (11449966), Sigrid Leyendecker (5829398), Henry van den Bedem (776295)   +2 more
core   +1 more source