Results 31 to 40 of about 2,014 (136)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease [PDF]

, 2014
Growth factors play important roles in synapse formation. Mouse models of neuropsychiatric diseases suggest that defects in synaptogenic growth factors, their receptors, and signaling pathways can lead to disordered neural development and various ...
Umemori, Hisashi, Williams, Aislinn J.
core   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Protein synthesis at synaptic sites on dendrites [PDF]

, 2001
Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1‐mTOR‐P‐gp axis

Epilepsia Open, EarlyView.
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Xiaomeng Wang, Rui Li, Yuzhu Zhang, Yi Hu, Jingjiao Chen, Sijia Tian, Dong Zhou, Xiaosa Chi   +7 more
wiley   +1 more source

Probable sepsis‐associated encephalopathy as a component of multiple organ dysfunction syndrome in a cat with pyothorax

Australian Veterinary Journal, EarlyView.
A 2‐year‐old male neutered domestic shorthair cat with bacterial pyothorax was referred to a tertiary hospital for treatment of sepsis. He met criteria for multiple organ dysfunction syndrome and developed new‐onset neurological dysfunction subsequent to the development of sepsis.
CC Chan, CR Sharp, CJ Boyd
wiley   +1 more source

Solving the Socratic Problem—A Contribution from Medicine [PDF]

, 2018
This essay provides a medical theory that could clarify enigmas surrounding the historical Socrates. It offers textual evidence that Socrates had temporal lobe epilepsy and that its two types of seizure manifested as recurrent voices and peculiar ...
Muramoto, Osamu
core  

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects [PDF]

, 2012
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have key ...
A Pavlowsky, A Pitkänen, A Pitkänen, A Vezzani, B Lee, BM Murphy, C Brandt, CH Kim, CM O'Tuathaigh, Colm O'Tuathaigh, David C Henshall, DH Bhatt, Donncha F O'Brien, DP Bartel, DP Wermeling, E Aronica, EM Jimenez-Mateos, EM Jimenez-Mateos, EM Jimenez-Mateos, Eva M Jimenez-Mateos, FV Karginov, G Mouri, G Sierra-Paredes, Genshin Mouri, GM Schratt, I Ballesteros-Yáñez, J DeFelipe, J Elmén, J Gao, J Krützfeldt, J Krützfeldt, J Nairismägi, J Noguchi, J Tao, J Wetherington, JA Saugstad, Javier DeFelipe, JE Cavazos, JO McNamara, John L Waddington, K Hu, Katsuhiro Tanaka, KL Stark, L Peters, LH Zeng, M Christensen, M Lagos-Quintana, M Matsuzaki, M Müller, M Segal, Michael A Farrell, N Rensing, Norman Delanty, P Merino-Serrais, P Penzes, Paula Merino-Serrais, Q Zhou, R Meller, Raymond L Stallings, Ronán M Conroy, Ross C McKiernan, S Halpain, S Shinoda, SM Eacker, Suzanne Prenter, T Araki, T Engel, T Engel, T Saneyoshi, Takanori Sano, Tobias Engel, UV Nägerl, V Ambros, Y Meng, YJ Song   +74 more
core   +3 more sources

Considering students' basic psychological needs in feedback processes in the teaching of Swedish

Foreign Language Annals, EarlyView.
Abstract This qualitative study investigated how teachers of Swedish as a second language in Finland perceive they enhance their students' language learning by considering the students' basic psychological needs in feedback processes. This study was conducted in a context where most students were disinclined to study Swedish.
Toni Mäkipää, Sara Karhu
wiley   +1 more source