Results 11 to 20 of about 2,014 (136)

Abnormal hippocampal melatoninergic system: a potential link between absence epilepsy and depression-like behavior in WAG/Rij rats? [PDF]

, 2018
Absence epilepsy and depression are comorbid disorders, but the molecular link between the two disorders is unknown. Here, we examined the role of the melatoninergic system in the pathophysiology of spike and wave discharges (SWDs) and depression-like ...
Battaglia, Giuseppe, Bucci, Domenico, Celli, Roberta, De Fusco, Antonio, Mastroiacovo, Federica, Moyanova, Slavianka, Nicoletti, Ferdinando, Santolini, Ines, Tchekalarova, Jane   +8 more
core   +1 more source

Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy. [PDF]

, 2018
Focal epilepsies represent approximately half of all diagnoses, and more than one-third of these patients are refractory to pharmacologic treatment.
Gurkoff, Gene, Izadi, Ali, Keselman, Inna, Ondek, Katelynn, Schedlbauer, Amber, Shahlaie, Kiarash   +5 more
core   +1 more source

Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility. [PDF]

, 2000
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state ...
Baram, TZ, Jensen, FE
core   +2 more sources

Depression in epilepsy. [PDF]

, 2017
PURPOSE OF REVIEW: To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future.
Mula, M
core   +1 more source

Alcohol Abuse Promotes Changes in Non-Synaptic Epileptiform Activity with Concomitant Expression Changes in Cotransporters and Glial Cells [PDF]

, 2013
Non-synaptic mechanisms are being considered the common factor of brain damage in status epilepticus and alcohol intoxication. the present work reports the influence of the chronic use of ethanol on epileptic processes sustained by non-synaptic ...
Aline Gisele Batista, Ana Paula Madureira, Antônio Márcio Rodrigues, Antônio-Carlos Guimarães de Almeida, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Fúlvio Alexandre Scorza, Gilcélio Amaral da Silveira, Henrique Alves Amorim, Luiz Eduardo Canton Santos, Mario Antônio Duarte, Ricardo Mário Arida, Ricardo Mário Arida, Victor Diego Cupertino Costa   +13 more
core   +2 more sources

The role of inflammation in epilepsy. [PDF]

, 2011
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures. Despite progress in pharmacological and surgical treatments of epilepsy, relatively little is known about the processes ...
A Crespel, A Iyer, A Liesz, A Mantovani, A Mouihate, A Pitkanen, A Pitkanen, A Vezzani, A Vezzani, A Vezzani, A Vezzani, A Vezzani, A Vincent, A Vincent, AL Lux, AM Iyer, Annamaria Vezzani, AR Crow, AR Ferguson, AT Berg, B Lee, B Viviani, B Viviani, B Voutsinos-Porche, BD Semple, BJ Baker, BJ Kelley, BT Hawkins, C Chen, C Cunningham, C Dubé, C Dubé, C Eriksson, C Marescaux, CA Dinarello, CA Dinarello, CA Pardo, CG Bien, CG Bien, CG Bien, CH Khuu, CK Glass, CM Dubé, CM Dubé, CN Davis, CR Plata-Salaman, D Shlosberg, D Stellwagen, DB Sinclair, E Aronica, E Lahat, E Lloyd, E Oby, E Perucca, E Wirrell, EA van Vliet, EH Wilson, EM Harre, F Clausen, F Dhote, F Villani, G De Sarro, GC Blobe, H Samland, H Verhelst, HH Ho, I Rozovsky, IJ Elenkov, IL Campbell, IV Tabarean, J Choi, J Dalmau, J Marcon, JA Aarli, JA French, JA Gorter, Jacqueline French, JG Heida, JH Xu, JM Pellock, JS Duncan, JW Wheless, K Akassoglou, K Boer, K Boer, K Hoebe, K Lukasiuk, K Riazi, K Yoshikawa, KA Kelley, KA Slanina, KH Jung, KJ Tracey, KL Brunson, KL Brunson, KL van Gassen, L Holtman, L Librizzi, L Longhi, LA O'Neill, LP Cacheaux, M Joels, M Majores, M Maldonado, M Maroso, M Minami, M Rizzi, M Sanchez-Alavez, M Sayyah, M Schwartz, M Utech, M Virta, M Wirenfeldt, M Zetterstrom, MA Galic, MA Mikati, MA Mikati, MA Rogawski, MD Nguyen, MF Tsan, MG De Simoni, MH Scantlebury, ML Foresti, MT Mackay, N Marchi, N Polascheck, NC Manley, ND Perkins, NJ Rothwell, NP Turrin, P Bezzi, PF Fabene, PF Fabene, PS Buckmaster, R Dantzer, R Mantegazza, R Riikonen, R Sapolsky, R Watson, R Zhang, RM Ransohoff, S Akira, S Auvin, S Auvin, S Balosso, S Balosso, S Gatti, S Haspolat, S Hu, S Najjar, SE Baranzini, SH Appel, SJ You, SK Kulkarni, SM Allan, SM Allan, SM Gloor, SW Rogers, T Bartfai, T Bartfai, T Cartmell, T Cullingford, T Ichiyama, T Rasmussen, T Ravizza, T Ravizza, T Ravizza, T Ravizza, T Ravizza, T Ravizza, Tallie Z. Baram, Tamas Bartfai, TD Gilmore, TZ Baram, TZ Baram, WA Banks, Y David, Y Takahashi, Y Wu, Z Kovacs, Z Szekanecz, ZQ Xiong   +181 more
core   +1 more source

The Role of Microbiota Metabolites Propionic Acid, p‐Cresol, and 4‐Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review

Autism Research, EarlyView.
ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni, Lisa Asta, Nicole Giompaolo, Rinvil Renaldi, Alberto Amaretti, Maddalena Rossi, Antonio M. Persico   +6 more
wiley   +1 more source

Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat [PDF]

, 2018
Case summary A 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity.
Gielen, Ingrid, Grinwis, Guy CM, Jurgens, Ben, Mandigers, Paul JJ, Meij, Björn P, Santifort, Koen M   +5 more
core   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source