An RNA‐binding atypical tropomyosin recruits kinesin‐1 dynamically to oskar mRNPs
EMBO Journal, 2016 Localization and local translation of oskar mRNA at the posterior pole of the Drosophila oocyte directs abdominal patterning and germline formation in the embryo. The process requires recruitment and precise regulation of motor proteins to form transport‐
semanticscholar +1 more source
From Fluctuations to Function: Unveiling the Role of Stochasticity in Life‐Like Systems
ChemSystemsChem, EarlyView.In this short review, we put forward the idea that randomly fluctuating, or stochastic, molecular events can and do play a role in the emergence of complex biological phenomena at longer length scales. There is a growing body of evidence of this occurring in natural systems, and we survey the computational and experimental attempts of researchers to ...
Aleksa Lakic, Alexander F. Mason
wiley +1 more source
Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases
Cell Reports, 2013 To elucidate the structural basis of the mechanism of microtubule depolymerization by kinesin-13s, we analyzed complexes of tubulin and the Drosophila melanogaster kinesin-13 KLP10A by electron microscopy (EM) and fluorescence polarization microscopy. We
Ana B. Asenjo +7 more
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Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. [PDF]
, 1992 M. Andrew Hoyt +3 more
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Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy
Future Medicinal Chemistry, 2016 The kinesin class of microtubule-associated motor proteins present attractive anti-cancer targets owing to their roles in key functions in dividing cells.
Stephanie M. Myers, I. Collins
semanticscholar +1 more source
MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families
Clinical Genetics, EarlyView.Pathogenic variants in MAP1B have recently emerged as a cause of neurodevelopmental disorders characterized by intellectual disability, epilepsy, and cortical malformations, including periventricular nodular heterotopia (PVNH) and polymicrogyria (PMG).
Jessica Archer +4 more
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Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. [PDF]
, 1992 Adriana Ferreira +4 more
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Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments. [PDF]
, 2011 Sensory cilia are assembled and maintained by kinesin-2-dependent intraflagellar transport (IFT). We investigated whether two Caenorhabditis elegans α- and β-tubulin isotypes, identified through mutants that lack their cilium distal segments, are ...
Acar, Seyda +8 more
core
Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes
, 2004 Kinesins are processive motor proteins that move along microtubules in a stepwise manner, and their motion is powered by the hydrolysis of ATP. Recent experiments have investigated the coupling between the individual steps of single kinesin molecules and
A. B. Kolomeisky +11 more
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Cell Proliferation, EarlyView.FAM20A variants cause AI1G, marked by enamel defects, gingival overgrowth and ectopic calcifications. RNA sequencing of patient‐derived gingival fibroblasts showed dysregulated genes in adhesion, proliferation and signalling pathways. Functional assays revealed increased cell proliferation, impaired ECM interactions and osteogenesis, suggesting FAM20A ...
Kanokwan Sriwattanapong +9 more
wiley +1 more source