Oxidative denaturation of Cu/Zn‐superoxide dismutase associated with neurodegenerative diseases
Protein Science, Volume 34, Issue 11, November 2025.Abstract Misfolding of mutant Cu/Zn‐superoxide dismutase (SOD1) is a well‐established pathological feature of familial amyotrophic lateral sclerosis (ALS). While amino acid substitutions in mutant SOD1 destabilize its structure and promote misfolding, oxidation has also been implicated in the pathological alterations of wild‐type SOD1, particularly in ...
Moeno Yoshida +9 more
wiley +1 more source
Kinesin undergoes a 9 S to 6 S conformational transition.
, 1992 David D. Hackney +2 more
openalex +1 more source
Phosphotransferases Associated with the Regulation of Kinesin Motor Activity [PDF]
, 1997 Lisa C. Lindesmith +3 more
openalex +1 more source
ChemMedChem, Volume 20, Issue 19, October 6, 2025.It is reported for the first time that atropisomeric (R)‐[1,1′‐binaphthalene]‐2,2′‐diamine (R‐BINAM, 1(R)), but not (S)‐[1,1′‐binaphthalene]‐2,2′‐diamine (S‐BINAM, 1(S)), is a moderately potent spindle poison, causing antiproliferation, depolymerization of microtubules, multipolar spindles, pericentriolar material (PCM) fragmentation, mitotic ...
Malte Eichelbaum, Patrick J. Bednarski
wiley +1 more source
Localization of the Kinesin-like Protein Xklp2 to Spindle Poles Requires a Leucine Zipper, a Microtubule-associated Protein, and Dynein [PDF]
, 1998 Torsten Wittmann +4 more
openalex +1 more source
Molecular Oncology, Volume 19, Issue 10, Page 2951-2966, October 2025.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
KIF2beta , a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation [PDF]
, 1998 Niovi Santama
openalex +1 more source
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Advanced Biology, Volume 9, Issue 10, October 2025.Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez +3 more
wiley +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, Volume 12, Issue 37, October 6, 2025.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon
Proceedings of the National Academy of Sciences of the United States of America, 2017 G. Farías +4 more
semanticscholar +1 more source