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Structures of kinesin and kinesin–microtubule interactions
Current Opinion in Cell Biology, 1999Several X-ray crystal structures of kinesin motor domains have recently been solved at high resolution ( approximately 0.2-0.3 nm), in both their monomeric and dimeric states. They show the folding of the polypeptide chain and different arrangements of subunits in the dimer.
Mandelkow, Eckhard, Hoenger, Andreas
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Kinesin-II, the heteromeric kinesin
Cellular and Molecular Life Sciences (CMLS), 1999The kinesins constitute a large family of motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. One class of these molecular motors, kinesin-II, is unique in that these proteins are typically found as heterotrimeric complexes containing two different, though related,
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Nature Reviews Cancer, 2012
Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development.
Oliver, Rath, Frank, Kozielski
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Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development.
Oliver, Rath, Frank, Kozielski
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Microtubule-Depolymerizing Kinesins
Annual Review of Cell and Developmental Biology, 2013The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from providing tracks for intracellular transport, to supporting movement of cilia and flagella, to segregating chromosomes in mitosis. These functions are facilitated by the organizational and dynamic plasticity of MT networks. An important class of enzymes that alters MT
Claire E, Walczak +2 more
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Roles of mitotic kinesins, kinesin-5 and kinesin-6, in regulating neuronal migation
2022Mammalian brain development depends on migration of newborn neurons from their sites of origin to new locales. Migration of the neuron involves the extension of a leading process followed by somal translocation. According to the existing literature, cytoplasmic dynein and myosin-II, a microtubule-based motor and an actin-based motor, respectively ...
Aditi Falnikar +2 more
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Microtubule-depolymerizing kinesins
Current Opinion in Cell Biology, 2005The fact that some kinesin-related proteins can destabilize microtubules is now a well-established fact. However, the contribution that these kinesins make to cellular function is just coming into focus. Key structural and kinetic studies on the mechanism of microtubule depolymerization by these kinesins have provided a framework for understanding ...
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Biochemistry, 2007
Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Flagellar Kinesins in Protists
Future Microbiology, 2011Cilia and flagella are organelles of the cell body present in many eukaryotic cells. Although their basic structure is well conserved from unicellular organisms to mammals, they show amazing diversity in number, structure, molecular composition, disposition and function.
William, Marande, Linda, Kohl
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1999
Abstract The heteromeric kinesins (or heterokinesins)1,2 are motor proteins that move towards the plus ends of microtubules at rates ∼0.3-0.6 µ,m s-1• They consist of two distinct heterodimerized kinesin subunits, and most motors of this class also contain an additional accessory subunit of unknown function.
Jonathan M Scholey, Karen P Wedaman
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Abstract The heteromeric kinesins (or heterokinesins)1,2 are motor proteins that move towards the plus ends of microtubules at rates ∼0.3-0.6 µ,m s-1• They consist of two distinct heterodimerized kinesin subunits, and most motors of this class also contain an additional accessory subunit of unknown function.
Jonathan M Scholey, Karen P Wedaman
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Trends in Neurosciences, 2018
Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Eva, Klinman, Erika L F, Holzbaur
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Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Eva, Klinman, Erika L F, Holzbaur
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