Results 251 to 260 of about 82,635 (293)
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Roles of mitotic kinesins, kinesin-5 and kinesin-6, in regulating neuronal migation
2022Mammalian brain development depends on migration of newborn neurons from their sites of origin to new locales. Migration of the neuron involves the extension of a leading process followed by somal translocation. According to the existing literature, cytoplasmic dynein and myosin-II, a microtubule-based motor and an actin-based motor, respectively ...
Aditi Falnikar +2 more
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Microtubule-depolymerizing kinesins
Current Opinion in Cell Biology, 2005The fact that some kinesin-related proteins can destabilize microtubules is now a well-established fact. However, the contribution that these kinesins make to cellular function is just coming into focus. Key structural and kinetic studies on the mechanism of microtubule depolymerization by these kinesins have provided a framework for understanding ...
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Biochemistry, 2007
Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Flagellar Kinesins in Protists
Future Microbiology, 2011Cilia and flagella are organelles of the cell body present in many eukaryotic cells. Although their basic structure is well conserved from unicellular organisms to mammals, they show amazing diversity in number, structure, molecular composition, disposition and function.
William, Marande, Linda, Kohl
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1999
Abstract The heteromeric kinesins (or heterokinesins)1,2 are motor proteins that move towards the plus ends of microtubules at rates ∼0.3-0.6 µ,m s-1• They consist of two distinct heterodimerized kinesin subunits, and most motors of this class also contain an additional accessory subunit of unknown function.
Jonathan M Scholey, Karen P Wedaman
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Abstract The heteromeric kinesins (or heterokinesins)1,2 are motor proteins that move towards the plus ends of microtubules at rates ∼0.3-0.6 µ,m s-1• They consist of two distinct heterodimerized kinesin subunits, and most motors of this class also contain an additional accessory subunit of unknown function.
Jonathan M Scholey, Karen P Wedaman
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Trends in Neurosciences, 2018
Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Eva, Klinman, Erika L F, Holzbaur
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Active intracellular transport of organelles relies on the coordinated activities of cytoplasmic dynein and kinesin, ATP-dependent microtubule motor proteins. While axonemal dynein was discovered during the mid-1960s, it was not until the mid-1980s that kinesin was discovered by Ron Vale and colleagues, as reported in 1985.
Eva, Klinman, Erika L F, Holzbaur
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1999
Abstract ‘Orphan’ kinesin refers to members of the kinesin superfamily which do not align closely to other kinesin classes based upon their motor domain sequences. Here, four kinesin orphans CENP-E, MKLP-1, nod, and kid are described, all of which appear to have important functions in chromosome segregation during mitosis or meiosis ...
Alastair Valentine Philp +1 more
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Abstract ‘Orphan’ kinesin refers to members of the kinesin superfamily which do not align closely to other kinesin classes based upon their motor domain sequences. Here, four kinesin orphans CENP-E, MKLP-1, nod, and kid are described, all of which appear to have important functions in chromosome segregation during mitosis or meiosis ...
Alastair Valentine Philp +1 more
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1999
Abstract Members of the Kin N bipolar class of kinesin motors have been identified from a variety of species including yeasts, Aspergillus, Drosophila, and Xenopus. All of these proteins have the motor domain at the N terminus, associate with spindle microtubules during mitosis, and appear to be involved in centrosome movement and ...
Krishanu Ray, Lawrence S B Goldstein
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Abstract Members of the Kin N bipolar class of kinesin motors have been identified from a variety of species including yeasts, Aspergillus, Drosophila, and Xenopus. All of these proteins have the motor domain at the N terminus, associate with spindle microtubules during mitosis, and appear to be involved in centrosome movement and ...
Krishanu Ray, Lawrence S B Goldstein
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Kinesin: world's tiniest biped
Current Opinion in Cell Biology, 2005Kinesin, an essential motor protein that moves intracellular cargo along microtubules, walks like a person. When we walk, our feet exchange roles with each step, one moving and one remaining stationary. The moving foot travels twice as far as our torso during a single step, and our body alternates between two configurations (left vs. right leg leading).
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1999
Abstract KIF1 (k.inesin superfamily protein 1) forms a subfamily of kinesin superfamily proteins that function as monomeric proteins associated with microtubule-based motor activity. 1 KIF1 A and KIF1B have been suggested to be involved in the intracellular transport of membranous organelles such as synaptic vesicle precursors and ...
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Abstract KIF1 (k.inesin superfamily protein 1) forms a subfamily of kinesin superfamily proteins that function as monomeric proteins associated with microtubule-based motor activity. 1 KIF1 A and KIF1B have been suggested to be involved in the intracellular transport of membranous organelles such as synaptic vesicle precursors and ...
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