Results 71 to 80 of about 3,799,045 (306)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Kinetic screening of nucleic acid ligand libraries for hit identification, binding mode characterization, and sequence optimization

open access: yesSensing and Bio-Sensing Research
Binding and unbinding rates are important characteristics of molecular interactions as they dictate binding affinities and complex lifetimes. Particularly, the engineering and maturation of nucleic acid-based ligands for therapeutic or diagnostic ...
Mareike C. De Pascali   +4 more
doaj   +1 more source

Comparison of CO2 gasification of coal in isothermal and non-isothermal conditions [PDF]

open access: yesE3S Web of Conferences, 2019
The thermogravimetric method allows to carry out measurements both in isothermal conditions for a given temperature and in non-isothermal conditions at a set heating rate. The aim of the work was to compare the process of gasification of the same coal in
Czerski Grzegorz   +2 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Determination of the kinetic parameters for crystallization directly from isothermal DSC curves

open access: yesDiscover Chemistry
The determination of crystallization kinetic parameters is central to elucidating the transformation mechanisms in glassy systems, particularly when analyzed within the framework of the Kolmogorov–Johnson–Mehl–Avrami equation. In this paper, we show that
Abdalla A. Elabbar   +1 more
doaj   +1 more source

Kinetic Profile of the Antioxidant Activity of Propolis Extract: 2,2-Diphenyl-1-Picrylhydrazyl Radical Bleaching Assay

open access: yesJournal of Apicultural Science, 2018
The objective of this paper was to assess the antiradical effectiveness of propolis extract (PE) based on 2.2-diphenyl-1-picrylhydrazyl radical (DPPH•) bleaching assay kinetic profile.
Mirković Snježana   +6 more
doaj   +1 more source

Retrievals of chlorine chemistry kinetic parameters from Antarctic ClO microwave radiometer measurements [PDF]

open access: yesAtmospheric Chemistry and Physics, 2011
Key kinetic parameters governing the partitioning of chlorine species in the Antarctic polar stratosphere were retrieved from 28 days of chlorine monoxide (ClO) microwave radiometer measurements made during the late winter/early spring of 2005 at Scott ...
S. Kremser   +12 more
doaj   +1 more source

The roles of kinetic theory and gas-surface interactions in measurements of upper-atmospheric density [PDF]

open access: yes, 1968
Kinetic theory and gas-surface interactions in measurements of upper atmospheric ...
Moe, M. M., Moe, K.
core  

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

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