Results 31 to 40 of about 2,148,955 (257)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundBacterial resistance to aminoglycoside antimicrobials is becoming increasingly severe due to their use as commonly prescribed antibiotics. The discovery of new molecular mechanisms of aminoglycoside resistance is critical for the effective ...
Naru Lin +9 more
doaj +1 more source
BMC Bioinformatics, 2022 Background Kinetic modeling is a powerful tool for understanding the dynamic behavior of biochemical systems. For kinetic modeling, determination of a number of kinetic parameters, such as the Michaelis constant (Km), is necessary, and global ...
Kazuhiro Maeda +4 more
doaj +1 more source
Challenges in Kinetic Parameter Determination for Wheat Straw Pyrolysis
Energies, 2022 Wheat straw is a renewable agricultural by-product that is currently underutilized in the production of bioenergy and bioproducts due to its high ash content, as well as high transport costs due to its low volumetric energy density. The thermogravimetric
Frederico G. Fonseca +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Determination of kinetic parameters for complex transesterification reaction by standard optimisation methods [PDF]
Hemijska Industrija, 2014 This article presents a methodology for kinetic parameter estimation which is based on standard optimization methods. The parameter estimation procedure is applied to the example of modelling of non-catalytic transesterification reaction, based ...
Almagrbi Abdualnaser Muftah +3 more
doaj +1 more source
Average Turbulence Dynamics from a One-Parameter Kinetic Theory
Atmosphere, 2023 We show theoretically that the mean turbulent dynamics can be described by a kinetic theory representation with a single free relaxation time that depends on space and time.
Hudong Chen +3 more
doaj +1 more source
Kinetic theory of aggregation in granular flow [PDF]
, 2011 This article presents a mathematical formulation of the aggregation kinetics in granular flow. The traditional kinetic theory and its generalized application to granular flow does not allow for particle size to change with time thus cannot be used to ...
L. Liu, Liu, L., Liu, Lande
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source