Results 41 to 50 of about 2,148,955 (257)
Frontiers in MicrobiologyBacterial resistance to aminoglycoside drugs is becoming increasingly severe due to their widespread use in agriculture and human medicine. Based on the whole-genome sequencing and molecular methods, a novel aminoglycoside resistance gene designated ...
Chaoqun Liu +12 more
doaj +1 more source
Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modelling
, 2002 A kinetic modelling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET) is presented. The approach is based on a general compartmental description of the tracer’s fate in vivo and determines a ...
Roger N. Gunn +14 more
core +1 more source
Kinetic model identification and parameters estimation from TGA experiments [PDF]
, 2007 The presented work is a part of an ongoing research effort on the development of a general methodology for the determination of kinetic models of solid thermal decomposition under pyrolysis conditions with thermogravimetric analysis (TGA) devices.
Cabassud, Michel +2 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Numerical Simulation of Hydrogen Combustion: Global Reaction Model and Validation
Frontiers in Energy Research, 2017 Due to the complexity of modeling the combustion process in nuclear power plants, the global mechanisms are preferred for numerical simulation. To quickly perform the highly resolved simulations with limited processing resources of large-scale hydrogen ...
Yun Zhang, Yun Zhang, Yinhe Liu
doaj +1 more source
Kinetic helicity and MHD turbulence [PDF]
, 2000 The issue of dynamical anisotropy in helical three-dimensional magnetohydrodynamic turbulence with a mean magnetic field B₀ is investigated. Using high-resolution direct numerical simulations, we follow the evolution of various isotropic initial states ...
Oughton, Sean, Prandi, Rossella
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundM. morganii is a species of the genus Morganella in the family Enterobacteriaceae. This species primarily causes infections of postoperative wounds and the urinary tract. Some isolates of M.
Runzhi Zhang +17 more
doaj +1 more source
Benchmarking optimization methods for parameter estimation in large kinetic models
, 2018 Software to reproduce the results presented in the paper "Benchmarking optimization methods for parameter estimation in large kinetic models". It includes two MATLAB toolboxes: AMICI and MEIGO, as well as MATLAB code to define the optimizations and to ...
Alejandro F. Villaverde +20 more
core +1 more source
A Novel High-Throughput FLIPR Tetra Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery [PDF]
, 2020 Target engagement by small-molecules is necessary for producing a physiological outcome. In the past, a lot of emphasis was placed on understanding the thermodynamics of such interactions to guide structure-activity relationship.
Puneet, Khurana +4 more
core +1 more source