Results 251 to 260 of about 900,715 (293)

Direct Observation of Protein−Ligand Interaction Kinetics

Biochemistry, 2003
Internal dynamics on the micro- to millisecond time scale have a strong influence on the affinity and specificity with which a protein binds ligands. This time scale is accessible through relaxation dispersion measurements using NMR. By studying the dynamics of a protein with different concentrations of a ligand, one can determine the dynamic effects ...
Tanja, Mittag, Brian, Schaffhausen, Ulrich L, Günther   +2 more
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Kinetic models of the drug-receptor interaction

Journal of Theoretical Biology, 1975
Abstract A model of drug action is proposed which is based upon intramolecular rearrangement of the drug-receptor complex. The model is a modification of classical occupancy theory kinetics. It is able to account for the transient excitatory response that is evoked by some blocking agents; it can also account for the phenomenon of “fade” (Paton, 1961)
R, Wilbur, E R, Fernholz, C T, Wilson
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Interaction kinetics of selenium-containing compounds with oxidants

Free Radical Biology and Medicine, 2020
Selenium compounds have been identified as potential oxidant scavengers for biological applications due to the nucleophilicity of Se, and the ease of oxidation of the selenium centre. Previous studies have reported apparent second order rate constants for a number of oxidants (e.g.
Carroll, Luke, Gardiner, Kelly, Ignasiak, Marta, Holmehave, Jeppe, Shimodaira, Shingo, Breitenbach, Thomas, Iwaoka, Michio, Ogilby, Peter R., Pattison, David, I, Davies, Michael J.   +9 more
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Mechanisms and kinetics of liposome–cell interactions

Advanced Drug Delivery Reviews, 1999
Although the possibility of targeting drugs to specific tissues and cells, as well as facilitating their uptake and cytoplasmic delivery has rendered liposomes a versatile drug carrier system with numerous potential applications in medicine, the molecular mechanisms of liposome-cell interactions are not understood well.
, Düzgüneş, , Nir
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Kinetics of Gas - Solid Interactions

1982
Publisher Summary This chapter investigates the heterogeneous chemical reaction of Ge and Si with active gases. The characteristics of the interaction of a Ge monocrystal with Br 2 is studied by means of kinetic and ellipsometric methods. The concentration dependence of the rate of the reaction is described by the kinetic equation W = KaP/( I + aP ).
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Kinetic study of lipoxygenase-hydroperoxylinoleic acid interaction

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1977
Interaction of lipoxygenase with hydroperoxylinoleic acid, which is the product of this enzyme reaction and acts as an activator, was studied kinetically by the fluorescence stopped-flow method. The kinetic features are consistent with a two-step mechanism involving a fast bimolecular association process followed by a slow unimolecular process.
H, Aoshima, T, Kajiwara, A, Hatanaka, H, Nakatani, K, Hiromi   +4 more
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Kinetic analysis of engineered antibody‐antigen interactions

Journal of Molecular Recognition, 1994
AbstractMolecular engineering antibodies has made it possible to produce specific domains of the antibody molecule and combine them with other protein domains to achieve new properties. Using site directed mutagenesis, amino acid residues can be exchanged within the binding site; and, by analysis of crystal structures, the positions of these amino ...
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KINETICS OF ALDOSE-AMINO ACID INTERACTION

Biochimica et Biophysica Acta, 1953
Abstract 1. 1. The kinetics of the reaction between various aldoses and amino acids and peptides has been investigated. 2. 2. A method for the determination of rate constants, based on the addition of alkali to keep the pH of the reaction mixture constant, has been developed. 3. 3.
A, KATCHALSKY, N, SHARON
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KINETICS OF ANTIBODY‐HAPTEN INTERACTIONS*^,†

Annals of the New York Academy of Sciences, 1963
While it was realized as early as 30 to 40 years ago that antibody—antigen reactions occur very rapidly (Hooker and Boyd, 1935; Mayer and Heidelberger, 1942), quantitative kinetic studies of both antibody—antigen and antibodyhapten reactions have come into prominence only during the past decade.
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Kinetics of Drug-Receptor Interaction

1977
Drugs can exert their pharmacological action in two different ways. First of all some drugs have an effect by virtue of their overall physicochemical characteristics (e.g., osmotic diuretics, antiseptics, antacids, and general anesthetics). Usually these are only effective in rather high concentrations, since they need to bring about changes in the ...
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