Results 51 to 60 of about 900,715 (293)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mathematical model of viral kinetics in vitro estimates the number of E2-CD81 complexes necessary for hepatitis C virus entry. [PDF]

PLoS Computational Biology, 2011
Interaction between the hepatitis C virus (HCV) envelope protein E2 and the host receptor CD81 is essential for HCV entry into target cells. The number of E2-CD81 complexes necessary for HCV entry has remained difficult to estimate experimentally.
Pranesh Padmanabhan, Narendra M Dixit
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Stability of Emergent Kinetics in Optical Lattices with Artificial Spin-Orbit Coupling

, 2016
Artificial spin-orbit coupling in optical lattices can be engineered to tune band structure into extreme regimes where the single-particle band flattens leaving only inter-particle interactions to define many-body states of matter. Lin et al. [Phys. Rev.
Chen, M., Scarola, V. W.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The nonlinear fragmentation equation

, 2007
We study the kinetics of nonlinear irreversible fragmentation. Here fragmentation is induced by interactions/collisions between pairs of particles, and modelled by general classes of interaction kernels, and for several types of breakage models.
Ernst, M. H., Pagonabarraga, I.
core   +2 more sources

Kinetic analysis of estrogen receptor/ligand interactions [PDF]

Proceedings of the National Academy of Sciences, 2002
Surface plasmon resonance biosensor technology was used to directly measure the binding interactions of small molecules to the ligand-binding domain of human estrogen receptor. In a screening mode, specific ligands of the receptor were easily discerned from nonligands.
Rebecca L, Rich, Lise R, Hoth, Kieran F, Geoghegan, Thomas A, Brown, Peter K, LeMotte, Samuel P, Simons, Preston, Hensley, David G, Myszka   +7 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

Frontiers in Pharmacology, 2019
The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear.
Saehyung Lee, Woo Sung Son, Ho Bin Yang, Nirmal Rajasekaran, Sung-Su Kim, Sungyoul Hong, Joon-Seok Choi, Jun Young Choi, Kyoung Song, Young Kee Shin, Young Kee Shin   +10 more
doaj   +1 more source

Statistical Derivation of Basic Equations of Diffusional Kinetics in Alloys with Application to the Description of Diffusion of Carbon in Austenite

, 2012
Basic equations of diffusional kinetics in alloys are statistically derived using the master equation approach. To describe diffusional transformations in substitution alloys, we derive the "quasi-equilibrium" kinetic equation which generalizes its ...
A. D. Clair Le, C. Domain, C. Kittel, C. Wells, D. E. Jiang, F. Soisson, G. Martin, G. V. Kurdyumov, H. K. D. H. Bhadeshia, I. A. Zhuravlev, J. Neuhaus, J. Zaretsky, J. Åren, J. Åren, J. Åren, J. Åren, J. Åren, K. D. Belashchenko, K. Yu. Khromov, L. D. Landau, L. Onsager, M. K. Miller, M. Nastar, M. Nastar, M. S. Blanter, P. Thibaux, R. P. Kolli, R. P. Smith, R. Rana, S. K. Satyia, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, V. G. Vaks, Y. L. Bouar   +41 more
core   +1 more source