Avidity of polyreactive immunoglobulins [PDF]
The Ukrainian Biochemical Journal, 2014 An analysis of the mechanism of interaction between polyreactive immunoglobulins (PRIG) and antigen was conducted and it was shown that most of the traditional methods of antibody affinity evaluation are not applicable for PRIG affinity. The comparative
S. A. Bobrovnik
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Fundamental differences between natural antibodies and polyreactive immunoglobulins [PDF]
The Ukrainian Biochemical Journal, 2015 A problem of similarity and differences between so-called polyreactive immunoglobulins (PRIGs) and natural antibodies (NAbs), capable of cross-reacting with some structurally dissimilar antigens, has been considered.
S. A. Bobrovnik +2 more
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Age changes of human serum polyreactive immunoglobulins (PRIG) activity [PDF]
The Ukrainian Biochemical Journal, 2014 It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy.
S. A. Bobrovnik +2 more
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Interaction peculiarities of polyreactive immunoglobulins and various antigens [PDF]
The Ukrainian Biochemical Journal, 2014 The influence of twin 20, lysozyme and protamine on the capability of polyreactive immunoglobulins (PRIG) to attach to various antigens was investigated.
S. A. Bobrovnik +2 more
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Antigen specificity affects analysis of natural antibodies [PDF]
Frontiers in ImmunologyNatural antibodies are used to compare immune systems across taxa, to study wildlife disease ecology, and as selection markers in livestock breeding. These immunoglobulins are present prior to immune stimulation.
Kendra Weston, Janet E. Fulton, Jeb Owen
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Kinetics of interaction between polyreactive immunoglobulins and antigen [PDF]
The Ukrainian Biochemical Journal, 2020 A number of experimental kinetics curves of mice polyreactive immunoglobulins (PRIGs) binding to ovalbumin immobilized on immunologic plates were obtained at different temperatures.
S. A. Bobrovnik +3 more
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Biological and immunochemical properties of polyreactive immunoglobulins [PDF]
The Ukrainian Biochemical Journal, 2015 A previously unknown phenomenon of acquired polyreactivity of serum immunoglobulins, which were subject to the effect of concentrated solutions of chaotropic ions, such as KSCN (3.0-5.0 M), low/high pH (pH 2.2-3.0), or heating to 58-60 °C, was originally
S. A. Bobrovnik +2 more
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Thermodynamics of interaction between polyreactive immunoglobulins and immobilized antigen [PDF]
The Ukrainian Biochemical Journal, 2021 In order to determine thermodynamic parameters of the interaction between polyreactive immunoglobulins (PRIGs) and immobilized antigen, several of experimental kinetic curves of PRIGs binding to immobilized ovalbumin were obtained at different ...
S. A. Bobrovnik +3 more
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Kinetics of interaction between polyreactive immunoglobulins and antigen. The theory [PDF]
The Ukrainian Biochemical Journal, 2019 Dynamics of association between polyreactive immunoglobulins (PRIGs) and immobilized antigens is considered on the base of our model of PRIGs-antigen interaction, which was suggested by us earlier.
S. A. Bobrovnik +2 more
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Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
Biomolecules, 2022 Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their ...
Anne K. Braczynski +12 more
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