Elevated Polyreactive Immunoglobulin G in Immune-Mediated Liver Injuries With the Need for Immunosuppressive Therapy. [PDF]
Liver IntABSTRACT Background & Aims The distinction of drug‐induced liver injury (DILI), drug‐induced autoimmune‐like hepatitis (DI‐ALH), and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker in AIH.
Kirchner T +18 more
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Kinetics of interaction between polyreactive immunoglobulins and antigen [PDF]
Ukrainian Biochemical Journal, 2020 A number of experimental kinetics curves of mice polyreactive immunoglobulins (PRIGs) binding to ovalbumin immobilized on immunologic plates were obtained at different temperatures.
S A Bobrovnik, S V Komisarenko
exaly +2 more sources
Antibody Polyreactivity: A Challenger of Immune Paradigms. [PDF]
ImmunologyThis review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Pashov AD, Dimitrov JD.
europepmc +2 more sources
Avidity of polyreactive immunoglobulins [PDF]
Ukrainian Biochemical Journal, 2014 An analysis of the mechanism of interaction between polyreactive immunoglobulins (PRIG) and antigen was conducted and it was shown that most of the traditional methods of antibody affinity evaluation are not applicable for PRIG affinity. The comparative
S A Bobrovnik
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Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies. [PDF]
Compr PhysiolEstrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
Kasibante J +3 more
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Interaction peculiarities of polyreactive immunoglobulins and various antigens [PDF]
Ukrainian Biochemical Journal, 2014 The influence of twin 20, lysozyme and protamine on the capability of polyreactive immunoglobulins (PRIG) to attach to various antigens was investigated.
S A Bobrovnik, S V Komisarenko
exaly +2 more sources
Antigen specificity affects analysis of natural antibodies [PDF]
Frontiers in ImmunologyNatural antibodies are used to compare immune systems across taxa, to study wildlife disease ecology, and as selection markers in livestock breeding. These immunoglobulins are present prior to immune stimulation.
Kendra Weston, Janet E. Fulton, Jeb Owen
doaj +2 more sources
Kinetics of interaction between polyreactive immunoglobulins and antigen. The theory [PDF]
Ukrainian Biochemical Journal, 2019 Dynamics of association between polyreactive immunoglobulins (PRIGs) and immobilized antigens is considered on the base of our model of PRIGs-antigen interaction, which was suggested by us earlier.
S A Bobrovnik, S V Komisarenko
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Age changes of human serum polyreactive immunoglobulins (PRIG) activity [PDF]
Ukrainian Biochemical Journal, 2014 It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy.
S A Bobrovnik, S V Komisarenko
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Biological and immunochemical properties of polyreactive immunoglobulins [PDF]
Ukrainian Biochemical Journal, 2015 A previously unknown phenomenon of acquired polyreactivity of serum immunoglobulins, which were subject to the effect of concentrated solutions of chaotropic ions, such as KSCN (3.0-5.0 M), low/high pH (pH 2.2-3.0), or heating to 58-60 °C, was originally
S A Bobrovnik, S V Komisarenko
exaly +2 more sources