Results 41 to 50 of about 935 (127)

Common idiotypes expressed on human, monoclonal, abnormal immunoglobulins and cryoglobulins with polyreaetive autoantibody activities [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYSeveral hutiian monoclonal immunoglobtilins with the same auloatitibody activity have been shown to have cross-reactive idiotypes (CRI). In this study, using polyclonal anti-idiotypic antibodies, we fotind that 28% of hutnan monoclonal immunoglobulins with polyreaetive autoantibody activity from myeloma.
M R, Barbouche, B, Guilbert, S, Makni, Y, Gorgi, K, Ayed, S, Avrameas   +5 more
openaire   +2 more sources

Treatment strategy for systemic lupus erythematosus using belimumab as indicated by multi‐omics analysis

Rheumatology &Autoimmunity, Volume 5, Issue 2, Page 81-87, June 2025.
Recent multi‐omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile. Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which is crucial for B cell differentiation, and
Keishi Fujio, Toshiyuki Ushijima, Tatsuki Abe, Tomohisa Okamura, Sang‐Cheol Bae, Yumi Tsuchida   +5 more
wiley   +1 more source

Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, and respiratory symptoms appearing 2–6 h after the consumption of mammalian ...
Rita Vaz‐Rodrigues, José de la Fuente
wiley   +1 more source

Polyreactive antibodies in multidonor-derived immunoglobulin G: Theory and conclusions drawn from experiments

Immunobiology, 2010
Multidonor-derived (md) preparations of IgG antibodies, agents of therapeutic potential, contain molecules interacting at clonal concentrations (concns) and with affinities recently estimated to cover a considerable range. Here we demonstrate that polyreactivity of the monomeric molecules represents the essential driving force of formation of the main ...
Peter, Gronski, Christian, Schridde, Horst-Dieter, Försterling   +2 more
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Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source

Self‐reactive B cells are increased in all major stages of peripheral development in Sjögren's disease

Immunology &Cell Biology, Volume 103, Issue 4, Page 401-410, April 2025.
In this article, we identify self‐reactive peripheral blood B cells in Sjögren's disease through a single‐cell culture system. We find 2‐ to 10‐fold increased frequencies of self‐reactive B cells during all stages of peripheral development in Sjögren's compared with healthy donors.
Adrian YS Lee, Zhankun Qi, Katherine JL Jackson, Joanne H Reed   +3 more
wiley   +1 more source

The interaction between polyreactive immunoglobulins and antigens is completely nonspecific

The Ukrainian Biochemical Journal
The interaction of PRIGs with various antigens differs radically from the interaction of specific antibodies and the corresponding antigen. First of all, this difference lies in the lower specificity of PRIGs, although there are other fundamental differences.
S. A. Bobrovnik, M. А. Demchenko, S. V. Komisarenko   +2 more
openaire   +1 more source

Intestinal mucosal immunity and type 1 diabetes: Non‐negligible communication between gut and pancreas

Diabetes, Obesity and Metabolism, Volume 27, Issue 3, Page 1045-1064, March 2025.
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell‐mediated pancreatic β cell loss, resulting in lifelong absolute insulin deficiency and hyperglycaemia. Environmental factors are recognized as a key contributor to the development of T1D, with the gut serving as a primary interface for environmental stimuli.
Ruonan Liu, Jing Zhang, Si Chen, Yang Xiao, Jingyi Hu, Zhiguang Zhou, Lingxiang Xie   +6 more
wiley   +1 more source

Detection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis

Hepatology International
Abstract Objective The detection of autoantibodies is essential to diagnose autoimmune hepatitis (AIH). Particularly in children, specificity of autoantibodies decreases due to lower titers being diagnostic and being present not only in AIH but also in other liver diseases.
Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina Luise, Kirchner, Theresa, Henjes, Nicole, Loges, Stephanie, Yuksel, Muhammed, Janczyk, Wojciech, Lalanne, Claudine, Zachou, Kalliopi, Oo, Ye, Gournay, Jérôme, Pape, Simon, Drenth, Joost, Renand, Amédée, Dalekos, George, Muratori, Luigi, Socha, Piotr, Ma, Yun, Arikan, Cigdem, Baumann, Ulrich, Manns, Michael, Wedemeyer, Heiner, Junge, Norman, Jaeckel, Elmar, Taubert, Richard   +25 more
openaire   +6 more sources

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source