Results 41 to 50 of about 28,096 (159)
B Cells Expressing a Natural Polyreactive Autoantibody Have a Distinct Phenotype and Are Overrepresented in Immunoglobulin Heavy Chain Transgenic Mice [PDF]
The Journal of Immunology, 2006 Abstract Despite stringent regulation of disease-associated autoantibodies, a substantial proportion of circulating Abs in sera of healthy individuals exhibit self-reactivity. These Abs are referred to as naturally occurring or natural autoantibodies (NAAs).
Qi, Tian +7 more
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states
, 2021 Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses.
Ermakov E.A.
core
Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley +1 more source
The effect of serum polyreactive immunoglobulins on antibody affinity determination
, 2010 Наличие в сыворотках животныx полиреактивных иммуноглобулинов может заметно повлиять на точность определения константы равновесия реакции взаимодействия специфичных антител и соответствующего антигена.
Комисаренко, С.В. +2 more
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The Influenza‐Specific Immunoglobulin Repertoire – Nimble Yet Steeped in Tradition
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Influenza virus has circulated in the human population and co‐evolved with us for centuries or longer, shaping our immune repertoires through a continuous host–virus arms race. Across individuals, antibodies repeatedly converge on shared solutions for capturing this shape‐shifting virus by precisely targeting conserved sites of vulnerability ...
Sarah F. Andrews, Masaru Kanekiyo
wiley +1 more source
Complement Factor H‐Based Therapeutics: A Comprehensive Overview
European Journal of Immunology, Volume 56, Issue 7, July 2026.Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers +2 more
wiley +1 more source
Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]
The Journal of experimental medicine, 1994 Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections. They are primarily immunoglobulin M (IgM) and bind a variety of structurally dissimilar self and exogenous antigens (Ags) with moderate affinity.
Ichiyoshi, Y, Casali, P
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Medicinal Research Reviews, Volume 46, Issue 3, Page 672-712, May 2026.ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
Common idiotypes expressed on human, monoclonal, abnormal immunoglobulins and cryoglobulins with polyreaetive autoantibody activities [PDF]
Clinical and Experimental Immunology, 1993 SUMMARYSeveral hutiian monoclonal immunoglobtilins with the same auloatitibody activity have been shown to have cross-reactive idiotypes (CRI). In this study, using polyclonal anti-idiotypic antibodies, we fotind that 28% of hutnan monoclonal immunoglobulins with polyreaetive autoantibody activity from myeloma.
M R, Barbouche +5 more
openaire +2 more sources