Results 41 to 50 of about 975 (147)
Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]
The Journal of experimental medicine, 1994 Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections. They are primarily immunoglobulin M (IgM) and bind a variety of structurally dissimilar self and exogenous antigens (Ags) with moderate affinity.
Ichiyoshi, Y, Casali, P
openaire +4 more sources
Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, and respiratory symptoms appearing 2–6 h after the consumption of mammalian ...
Rita Vaz‐Rodrigues, José de la Fuente
wiley +1 more source
The Human B Cell Response to a Multi-Antigen Complex (Bexsero) [PDF]
, 2018 Multi-Antigen-Komplexe wurden in der Vakzinologie als effizientes Modell genutzt, um eine breite Impfstoffabdeckung gegen mehrere Stämme desselben Pathogens zu erzielen.
Yalley, Prince
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Maternal IgE Influence on Fetal and Infant Health
Immunological Reviews, Volume 331, Issue 1, May 2025.ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla +2 more
wiley +1 more source
, 2017 The pathogenesis of Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas (OAEMZLs) is poorly understood. OAEMZLs are monoclonal tumors expressing a biased repertoire of mutated surface immunoglobulins. Antigenic activation of
Zhu, D.;Bhatt, S.;Lu, X.;Guo, F.;Veelken, H.;Hsu, D. K.;Liu, F-T;Cubela, S. Alvarez;Kunkalla, K.;Vega, F.;Chapman-Fredricks, J. R.;Lossos, I. S.
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Common idiotypes expressed on human, monoclonal, abnormal immunoglobulins and cryoglobulins with polyreaetive autoantibody activities [PDF]
Clinical and Experimental Immunology, 1993 SUMMARYSeveral hutiian monoclonal immunoglobtilins with the same auloatitibody activity have been shown to have cross-reactive idiotypes (CRI). In this study, using polyclonal anti-idiotypic antibodies, we fotind that 28% of hutnan monoclonal immunoglobulins with polyreaetive autoantibody activity from myeloma.
M R, Barbouche +5 more
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Immunology &Cell Biology, Volume 103, Issue 4, Page 401-410, April 2025.In this article, we identify self‐reactive peripheral blood B cells in Sjögren's disease through a single‐cell culture system. We find 2‐ to 10‐fold increased frequencies of self‐reactive B cells during all stages of peripheral development in Sjögren's compared with healthy donors.
Adrian YS Lee +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 27, Issue 3, Page 1045-1064, March 2025.Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell‐mediated pancreatic β cell loss, resulting in lifelong absolute insulin deficiency and hyperglycaemia. Environmental factors are recognized as a key contributor to the development of T1D, with the gut serving as a primary interface for environmental stimuli.
Ruonan Liu +6 more
wiley +1 more source
Know Your ABCs: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT Since their first description in 2008, T‐bet+ B cells have emerged as a clinically important B cell subset. Now commonly known as ABCs (Age‐associated B Cells), they are uniquely characterized by their expression of the transcription factor T‐bet. Indeed, this singular factor defines this B cell subset.
Gary M. Winslow, Russell Levack
wiley +1 more source
Immunobiology, 2010 Multidonor-derived (md) preparations of IgG antibodies, agents of therapeutic potential, contain molecules interacting at clonal concentrations (concns) and with affinities recently estimated to cover a considerable range. Here we demonstrate that polyreactivity of the monomeric molecules represents the essential driving force of formation of the main ...
Peter, Gronski +2 more
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