Results 51 to 60 of about 975 (147)

Signaling Activation and Modulation in Extrafollicular B Cell Responses

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT The differentiation of naive follicular B cells into either the germinal center (GC) or extrafollicular (EF) pathway plays a critical role in shaping the type, affinity, and longevity of effector B cells. This choice also governs the selection and survival of autoreactive B cells, influencing their potential to enter the memory compartment ...
Julian Staniek, Marta Rizzi
wiley   +1 more source

Nanobody engineering: computational modelling and design for biomedical and therapeutic applications

FEBS Open Bio, Volume 15, Issue 2, Page 236-253, February 2025.
This review focuses on structural characteristics, functional properties, and computational approaches driving the design and optimisation of synthetic nanobodies. We discuss recent advancements in computational methods for nanobody modelling, epitope prediction, and affinity maturation, shedding light on their intricate antigen‐binding mechanisms and ...
Nehad S. El Salamouni, Jordan H. Cater, Lisanne M. Spenkelink, Haibo Yu   +3 more
wiley   +1 more source

Novel insights into the molecular pathogenesis of gastric MALT lymphoma [PDF]

, 2010
Gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) represents a distinct class of extranodal lymphoma that evolves against a background of chronic inflammation induced by persistent infection with the bacterium ...
Craig, Vanessa Jane
core   +1 more source

The interaction between polyreactive immunoglobulins and antigens is completely nonspecific

The Ukrainian Biochemical Journal
The interaction of PRIGs with various antigens differs radically from the interaction of specific antibodies and the corresponding antigen. First of all, this difference lies in the lower specificity of PRIGs, although there are other fundamental differences.
S. A. Bobrovnik, M. А. Demchenko, S. V. Komisarenko   +2 more
openaire   +1 more source

Detection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis

Hepatology International
Abstract Objective The detection of autoantibodies is essential to diagnose autoimmune hepatitis (AIH). Particularly in children, specificity of autoantibodies decreases due to lower titers being diagnostic and being present not only in AIH but also in other liver diseases.
Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina Luise, Kirchner, Theresa, Henjes, Nicole, Loges, Stephanie, Yuksel, Muhammed, Janczyk, Wojciech, Lalanne, Claudine, Zachou, Kalliopi, Oo, Ye, Gournay, Jérôme, Pape, Simon, Drenth, Joost, Renand, Amédée, Dalekos, George, Muratori, Luigi, Socha, Piotr, Ma, Yun, Arikan, Cigdem, Baumann, Ulrich, Manns, Michael, Wedemeyer, Heiner, Junge, Norman, Jaeckel, Elmar, Taubert, Richard   +25 more
openaire   +6 more sources

Variable region gene expression and structural motifs of human polyreactive immunoglobulins

, 1997
University of Technology, Sydney. Faculty of Science.Polyreactive immunoglobulins (Ig) exhibit a capacity to recognise multiple, structurally dissimilar antigens through a single combining site.
Ramsland, PA
core  

Trypanosoma cruzi infection enhances polyreactive antibody response in an acute case of human Chagas' disease

, 1993
SUMMARY The kinetics of antibody response in an acute case of human Chagas' disease was investigated. Hypergammaglubulinaemia appeared at day 17 of infection, and persisted after 66 days of infection, at which time parasitaemia became ...
M HOUDAYER, M HONTEBEYRIE-JOSKOWCIZ, M R GRAUERT   +2 more
core   +1 more source

B-1 lymphocyte population and their role in the development of autoimmune diseases [PDF]

, 2016
B-1 lymphocytes are specific type of B cells, development of witch occurs primarily in neonatal period of life. Later, the population is maintained through self-renewel.
Jabůrek, Filip
core  

B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis

, 2010
Gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) develops in the context of chronic inflammation caused by Helicobacter pylori infection. Most pathophysiological features of the early stages of MALT lymphomagenesis can be reproduced by
Cogliatti, S B, Gerke, C, Craig, V J, Cogliatti, S. B., Balandat, J.-E., Müller, A., Arnold, I, Arnold, I., Wündisch, T., Wündisch, T, Craig, V. J., Müller, Anne; https://orcid.org/, Balandat, J-E, Gerke, C.   +13 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source