Results 51 to 60 of about 28,096 (159)
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Complement activation is a major barrier to xenotransplantation. We report detailed complement monitoring in a 58‐year‐old man who received a 10 gene–edited porcine heart expressing human complement regulators CD46 and CD55. Despite these transgenes and prophylactic systemic complement inhibition with C1 esterase inhibitor (C1INH), early ...
Michael A. Cole +25 more
wiley +1 more source
Quantification of Polyreactive Antibodies in Cardiolipin Using Dinitrophenol
, 2022 Antibodies play a critical role in the immune system to recognize and defend the body from antigens. While most antibodies bind to one unique antigen due to the affinity maturation process, some antibodies bind with low affinity to multiple unrelated ...
Feliciano, Keira, Rodriguez, Vanessa
core
The interaction between polyreactive immunoglobulins and antigens is completely nonspecific
The Ukrainian Biochemical JournalThe interaction of PRIGs with various antigens differs radically from the interaction of specific antibodies and the corresponding antigen. First of all, this difference lies in the lower specificity of PRIGs, although there are other fundamental differences.
S. A. Bobrovnik +2 more
openaire +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, Volume 599, Issue 20, Page 2896-2910, October 2025.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Variable region gene expression and structural motifs of human polyreactive immunoglobulins [PDF]
, 1997 University of Technology, Sydney. Faculty of Science.Polyreactive immunoglobulins (Ig) exhibit a capacity to recognise multiple, structurally dissimilar antigens through a single combining site.
Ramsland, PA
core
, 2017 Understanding the B-cell response during chronic human immunodeficiency virus (HIV) infection is essential for eliciting broad and potent neutralizing antibodies (Abs).
Kaihong Su +6 more
core +1 more source
Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets
MedComm, Volume 6, Issue 7, July 2025.This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song +9 more
wiley +1 more source
Sialylated Immunoglobulins for the Treatment of Immuno-Inflammatory Diseases
, 2020 Immunoglobulins are the potent effector proteins of the humoral immune response. In the course of evolution, immunoglobulins have formed extremely diverse types of molecular structures with antigen-recognizing, antigen-binding, and effector functions ...
Alexander N. Orekhov +6 more
core +1 more source
, 2022 Supplemental data concerning our study "Intravenous and subcutaneous immunoglobulins-associated eczematous reactions occur with a broad range of immunoglobulins types : a French national multicenter study"THIS DATASET IS ARCHIVED AT DANS/EASY,
VOLAND, P (via Mendeley Data) +1 more
core +1 more source
Use of Intravenous Immunoglobulins in Intensive Therapy [PDF]
, 2012 The main cause of death in the intensive care units is infectious complications, including sepsis and septic shock. Immunoglobulins are the most potent mechanisms in anti-infective defense.
E. A. Latysheva, T. V. Latysheva
core +1 more source