Results 31 to 40 of about 975 (147)

Noninvasive Monitoring of Complement Using the Bioluminescent Modified Ham Assay in the Second Porcine‐to‐Human Live Heart Transplant

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Complement activation is a major barrier to xenotransplantation. We report detailed complement monitoring in a 58‐year‐old man who received a 10 gene–edited porcine heart expressing human complement regulators CD46 and CD55. Despite these transgenes and prophylactic systemic complement inhibition with C1 esterase inhibitor (C1INH), early ...
Michael A. Cole, Andy Tully, Javier Galindo, Avneesh K. Singh, Meryl Waldman, Janhavi Athale, Idris Boudhabhay, Erwan Morgand, Fariza Mezine, Valentin Goutaudier, Aurélie Sannier, Brad Lewis, Jamey Kain, Mike Ero, Lubka Roumenina, Patrick Bruneval, Robert Christenson, Lo Tamburro, Alan Burke, Cinthia Drachenburg, Alexandre Loupy, David Ayares, Robert A. Brodsky, Bartley P. Griffith, Muhammad M. Mohiuddin, Alison Grazioli   +25 more
wiley   +1 more source

Polyreactive Autoantibodies Purified from Human Intravenous Immunoglobulins Prevent the Development of Experimental Autoimmune Diseases [PDF]

Laboratory Investigation, 2003
Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human polyclonal Ig G (IgG) that exert immunomodulatory effects in patients with autoimmune or systemic inflammatory diseases. Two different IgG subfractions were evaluated for their respective immunomodulatory effects in the treatment of experimental autoimmune diseases: a ...
Martine, Bruley-Rosset, Luc, Mouthon, Youri, Chanseaud, Frédéric, Dhainaut, Jacky, Lirochon, Dominique, Bourel   +5 more
openaire   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, Volume 599, Issue 20, Page 2896-2910, October 2025.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states

, 2021
Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses.
Ermakov E.A.
core  

The effect of serum polyreactive immunoglobulins on antibody affinity determination

, 2010
Наличие в сыворотках животныx полиреактивных иммуноглобулинов может заметно повлиять на точность определения константы равновесия реакции взаимодействия специфичных антител и соответствующего антигена.
Комисаренко, С.В., Демченко, М.А., Бобровник, С.А.   +2 more
core   +1 more source

B Cells Expressing a Natural Polyreactive Autoantibody Have a Distinct Phenotype and Are Overrepresented in Immunoglobulin Heavy Chain Transgenic Mice [PDF]

The Journal of Immunology, 2006
Abstract Despite stringent regulation of disease-associated autoantibodies, a substantial proportion of circulating Abs in sera of healthy individuals exhibit self-reactivity. These Abs are referred to as naturally occurring or natural autoantibodies (NAAs).
Qi, Tian, Michael, Beardall, Yang, Xu, Ju, Li, David C, Parker, Nina, Casanova, Anthony C, Bakke, Ching, Chen   +7 more
openaire   +2 more sources

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus exhibits constitutive activation of nearly all major inflammatory pathways, including sterile MyD88‐dependent signaling and interferon production by mTECs, the presence of cellular and molecular components of type 1, type 2, and type 3 responses, as well as sustained B cell activation. The reasons for the existence of such a complex
Taras Kreslavsky
wiley   +1 more source

Recruitment of Rab27a to Phagosomes Controls Microbial Antigen Cross-Presentation by Dendritic Cells

, 2008
Polyreactive immunoglobulins (Ig) and complement components are present in tissues and blood of healthy individuals. They facilitate pathogen uptake and inactivation in lysosomes of phagocytes and thereby provide rapid protection against infection ...
Carin Cruijsen, Marianne Boes, Seong Hyun Kim, Annelies Visser, Adrianus W. M. van der Velden   +4 more
core   +1 more source

Treatment strategy for systemic lupus erythematosus using belimumab as indicated by multi‐omics analysis

Rheumatology &Autoimmunity, Volume 5, Issue 2, Page 81-87, June 2025.
Recent multi‐omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile. Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which is crucial for B cell differentiation, and
Keishi Fujio, Toshiyuki Ushijima, Tatsuki Abe, Tomohisa Okamura, Sang‐Cheol Bae, Yumi Tsuchida   +5 more
wiley   +1 more source