Results 31 to 40 of about 28,096 (159)

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

Polyreactive Autoantibodies Purified from Human Intravenous Immunoglobulins Prevent the Development of Experimental Autoimmune Diseases [PDF]

Laboratory Investigation, 2003
Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human polyclonal Ig G (IgG) that exert immunomodulatory effects in patients with autoimmune or systemic inflammatory diseases. Two different IgG subfractions were evaluated for their respective immunomodulatory effects in the treatment of experimental autoimmune diseases: a ...
Martine, Bruley-Rosset, Luc, Mouthon, Youri, Chanseaud, Frédéric, Dhainaut, Jacky, Lirochon, Dominique, Bourel   +5 more
openaire   +2 more sources

Recruitment of Rab27a to Phagosomes Controls Microbial Antigen Cross-Presentation by Dendritic Cells

, 2008
Polyreactive immunoglobulins (Ig) and complement components are present in tissues and blood of healthy individuals. They facilitate pathogen uptake and inactivation in lysosomes of phagocytes and thereby provide rapid protection against infection ...
Carin Cruijsen, Marianne Boes, Seong Hyun Kim, Annelies Visser, Adrianus W. M. van der Velden   +4 more
core   +1 more source

Activation of Anergic B Cells During Development of Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT In healthy individuals, autoreactive B cells are normally silenced via central and peripheral tolerance mechanisms. In the periphery, when autoreactive B cells recognize self‐antigen via their B cell receptor (BCR) (signal 1) but do not receive T cell help (signal 2), they undergo the tolerance mechanism called anergy.
Mohammad Mansoor, Brandon K. Hilliard, Mia J. Smith   +2 more
wiley   +1 more source

Preparation and Characterization of Nano-size Polyreactive Blue MXR

, 2012
Nanosize Polyreactive blue MXR dye was synthesized from reactive blue MXR dye in presence of potassium persulfate as catalyst. The formation of polyreactive blue MXR was indicated by colour change from blue to brown.
Joghee Suresh, Raja Gopal Rajiv Gandhi, Mahalingam Sundrarajan, Sundaram Gowri, Samayanan Selvam   +4 more
core   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Role of polyreactive autoantibodies in the physiopathology of Sjögren’s Syndrome [PDF]

Programa de Doctorat en Biomedicina[eng] Sjögren's syndrome (SjS) is a chronic autoimmune disease that mainly affects the exocrine glands and is characterized by the presence of antinuclear antibodies such as anti-Ro52 and anti-dsDNA.
Gutiérrez Cózar, Rebeca
core   +3 more sources

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated [PDF]

, 2011
The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission ...
Sonya L. Heath, Michael Egholm, Chen, Xi, Simen, Birgitte B, Bar, Katharine J, Haynes, Barton F, Denny, Thomas N, George C. Shaw, Boyd, Scott D, Boyd, Scott D., Egholm, Michael, S. Munir Alam, Eleanor Marshal, Zhang, Ruijun, Shaw, George C, Liao, Hua-Xin, Denny, Thomas N., Scott D. Boyd, Moody, M. Anthony, Xiaozhi Lu, Georgia D. Tomaras, Kepler, Thomas B, Marshall, Dawn J., Lu, Xiaozhi, Bar, Katharine J., Voss, Gerald, Xi Chen, Yu, Jae-Sung, Ruijun Zhang, Paul A. Goepfert, Munshaw, Supriya, Whitesides, John F, Thomas N. Denny, Shaw, George C., Gerald Voss, Alam, S Munir, Hwang, Kwan Ki, Feng Gao, Garnett Kelsoe, Montefiori, David C, Fire, Andrew Z., M. Anthony Moody, Goepfert, Paul A., Goepfert, Paul A, Heath, Sonya L., Simen, Birgitte B., Kelsoe, Garnett, Nathan Vandergrift, Kepler, Thomas B., Fire, Andrew Z, David C. Montefiori, Heath, Sonya L, Markowitz, Martin, Supriya Munshaw, Barton F. Haynes, Yu, Jae Sung, Andrew Z. Fire, Hwang, Kwan-Ki, Birgitte B. Simen, Thomas B. Kepler, Katharine J. Bar, Moody, M Anthony, Kwan-Ki Hwang, Gao, Feng, Whitesides, John F., Margolis, David M., Dawn J. Marshall, Marshall, Dawn J, David M. Margolis, Liao, Hua Xin, Marshal, Eleanor, Tomaras, Georgia D., John F. Whitesides, Hua-Xin Liao, Jae-Sung Yu, Alam, S. Munir, Martin Markowitz, Tomaras, Georgia D, Hanczaruk, Bozena, Montefiori, David C., Margolis, David M, Bozena Hanczaruk, Vandergrift, Nathan, Haynes, Barton F.   +83 more
core   +1 more source