Fundamental differences between natural antibodies and polyreactive immunoglobulins [PDF]
Ukrainian Biochemical Journal, 2015 A problem of similarity and differences between so-called polyreactive immunoglobulins (PRIGs) and natural antibodies (NAbs), capable of cross-reacting with some structurally dissimilar antigens, has been considered.
S A Bobrovnik, S V Komisarenko
exaly +6 more sources
Thermodynamics of interaction between polyreactive immunoglobulins and immobilized antigen [PDF]
The Ukrainian Biochemical Journal, 2021 In order to determine thermodynamic parameters of the interaction between polyreactive immunoglobulins (PRIGs) and immobilized antigen, several of experimental kinetic curves of PRIGs binding to immobilized ovalbumin were obtained at different ...
S. A. Bobrovnik +3 more
doaj +2 more sources
Kinetic parameters of polyreactive immunoglobulins interaction with antigens in the presence of protamine [PDF]
The Ukrainian Biochemical Journal, 2016 The discovered earlier phenomenon of the enhancment of polyreactive immunoglobulines (PRIGs) binding to antigens in the presence of protamine and Tween 20 was investigated in more details.
S. A. Bobrovnik +2 more
doaj +3 more sources
Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis [PDF]
Frontiers in Immunology, 2018 Secretory immunoglobulins have a critical role in defense of the gastrointestinal tract and are known to act by preventing bacterial acquisition. A stringent murine model of bacterial infection with Salmonella enterica Typhimurium was used to examine ...
Blaise Corthésy +5 more
doaj +2 more sources
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
Biomolecules, 2022 Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their ...
Anne K. Braczynski +12 more
doaj +2 more sources
Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes [PDF]
Leukemia & Lymphoma, 2018 Polyreactive antibodies are a major part of natural antibody repertoire and can react with different types of antigens both from the host (e.g.
Ying Xiong +7 more
core +3 more sources
Polyreactive Binding of Antibodies Generated by Polyclonal B Cell Activation. I. Polyreactivity Could be Caused by Differential Glycosylation of Immunoglobulins [PDF]
Scandinavian Journal of Immunology, 1997 The aim of this study was to gain knowledge of the pre‐immune repertoire with reactivity directed to the carbohydrate antigen dextran B512 (Dx). Polyclonal activation of spleen cells in mice has been estimated to be a method of revealing the available repertoire.
C. FERNÁNDEZ +4 more
core +3 more sources
Diverse binding site structures revealed in homology models of polyreactive immunoglobulins
Journal of Computer-Aided Molecular Design, 1997 We describe here computer-assisted homology models of the combining site structure of three polyreactive immunoglobulins. Template-based models of Fv (V-V) fragments were derived for the surface IgM expressed by the malignant CD5 positive B cells from ...
P.A.Ramsland P.A.RamslandPaul A.P.A.Ramsland P.RamslandPaul A.https://api.elsevier.com/content/author/author_id/7004592319
core +5 more sources
Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis [PDF]
Hepatology, 2021 Abstract Background and Aims Detection of autoantibodies is a mainstay of diagnosing autoimmune hepatitis (AIH). However, conventional autoantibodies for the workup of AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty.
Taubert, Richard +37 more
openaire +10 more sources
Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens [PDF]
The Ukrainian Biochemical Journal, 2018 The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal ...
S. A. Bobrovnik +2 more
doaj +1 more source