Results 11 to 20 of about 28,096 (159)

Elevated Polyreactive Immunoglobulin G in Immune-Mediated Liver Injuries With the Need for Immunosuppressive Therapy. [PDF]

Liver Int
ABSTRACT Background & Aims The distinction of drug‐induced liver injury (DILI), drug‐induced autoimmune‐like hepatitis (DI‐ALH), and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics.
Kirchner T, Dalekos GN, Zachou K, Robles-Díaz M, Andrade RJ, Sebode M, Lohse A, Janik MK, Milkiewicz P, Kolev M, Semmo N, Bruns T, Gevers TJ, Beretta-Piccoli BT, Wedemeyer H, Jaeckel E, Taubert R, Engel B, pIgG study group.   +18 more
europepmc   +5 more sources

Kinetic parameters of polyreactive immunoglobulins interaction with antigens in the presence of protamine [PDF]

The Ukrainian Biochemical Journal, 2016
The discovered earlier phenomenon of the enhancment of polyreactive immunoglobulines (PRIGs) binding to antigens in the presence of protamine and Tween 20 was investigated in more details.
S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko   +2 more
doaj   +3 more sources

Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis [PDF]

Frontiers in Immunology, 2018
Secretory immunoglobulins have a critical role in defense of the gastrointestinal tract and are known to act by preventing bacterial acquisition. A stringent murine model of bacterial infection with Salmonella enterica Typhimurium was used to examine ...
Blaise Corthésy, Justine Monnerat, Marius Lötscher, Cédric Vonarburg, Alexander Schaub, Gilles Bioley   +5 more
doaj   +2 more sources

Antibody Polyreactivity: A Challenger of Immune Paradigms. [PDF]

Immunology
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Pashov AD, Dimitrov JD.
europepmc   +2 more sources

Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies. [PDF]

Compr Physiol
Estrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
Kasibante J, Brown TT, Lake JE, Abdel-Mohsen M.   +3 more
europepmc   +2 more sources

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis [PDF]

Hepatology, 2021
Abstract Background and Aims Detection of autoantibodies is a mainstay of diagnosing autoimmune hepatitis (AIH). However, conventional autoantibodies for the workup of AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty.
Taubert, Richard, Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina L., Behrendt, Patrick, Baerlecken, Niklas T., Sühs, Kurt-Wolfram, Janik, Maciej K., Zachou, Kalliopi, Sebode, Marcial, Schramm, Christoph, Londoño, María-Carlota, Habes, Sarah, UK-AIH Consortium, Oo, Ye H., Lalanne, Claudine, Pape, Simon, Schubert, Maren, Hust, Michael, Dübel, Stefan, Thevis, Mario, Jonigk, Danny, Beimdiek, Julia, Buettner, Falk F. R., Drenth, Joost P. H., Muratori, Luigi, Adams, David H., Dyson, Jessica K., Renand, Amédée, Graupera, Isabel, Lohse, Ansgar W., Dalekos, George N., Milkiewicz, Piotr, Stangel, Martin, Maasoumy, Benjamin, Witte, Torsten, Wedemeyer, Heiner, Manns, Michael P., Jaeckel, Elmar   +38 more
openaire   +9 more sources

Genetic evidence suggests a protective role of immunoglobulin M in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Immune dysfunction has been implicated in Alzheimer's disease (AD), but the roles of specific immunoglobulin classes remain unclear. METHODS We integrated human genetics and plasma biomarker analyses to evaluate immunoglobulin G (IgG), IgA, and IgM in relation to AD.
Peng S, Butler-Laporte G, Johnson SC, Engelman CD, Lu T.   +4 more
europepmc   +2 more sources

BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity. [PDF]

Immunol Rev
ABSTRACT BAFF and APRIL are TNF superfamily proteins that bind to BAFFR, TACI and BCMA, members of the TNF receptor superfamily. These proteins have both unique and overlapping roles in B cell development and survival and are major therapeutic targets for antibody‐ and B‐cell‐driven pathologies.
Luff DH, Schweighoffer E, Tybulewicz VLJ.   +2 more
europepmc   +2 more sources

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens [PDF]

The Ukrainian Biochemical Journal, 2018
The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal ...
S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

Inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine [PDF]

The Ukrainian Biochemical Journal, 2016
The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and ...
V. M. Danilova, R. P. Vynogradova, S. G. Torkhova   +2 more
doaj   +1 more source