Results 11 to 20 of about 935 (127)

Antibody Polyreactivity: A Challenger of Immune Paradigms. [PDF]

Immunology
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Pashov AD, Dimitrov JD.
europepmc   +2 more sources

Antigen specificity affects analysis of natural antibodies [PDF]

Frontiers in Immunology
Natural antibodies are used to compare immune systems across taxa, to study wildlife disease ecology, and as selection markers in livestock breeding. These immunoglobulins are present prior to immune stimulation.
Kendra Weston, Janet E. Fulton, Jeb Owen
doaj   +2 more sources

Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies. [PDF]

Compr Physiol
Estrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
Kasibante J, Brown TT, Lake JE, Abdel-Mohsen M.   +3 more
europepmc   +2 more sources

Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins [PDF]

Blood, 2010
Abstract Gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arises against a background of chronic inflammation caused by persistent Helicobacter pylori infection. The clinical and histopathologic features of the human tumor can be reproduced by Helicobacter infection of BALB/c mice.
Christoph Renner, Falkow Stanley, Müller Anne   +2 more
exaly   +4 more sources

Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection

Transplant Immunology
Chronic rejection remains an obstacle to long-term allograft survival. Donor-specific anti-HLA antibodies (DSA) play a significant role in causing chronic antibody-mediated allograft rejection. Exposure to mismatched HLA antigens via transfusion, pregnancy, or transplanted tissue has been described in the literature as an immunogenic stimulus of anti ...
Steven D, Heron, Jim, Shaw, Johannes, Dapprich   +2 more
exaly   +3 more sources

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis [PDF]

Hepatology, 2021
Abstract Background and Aims Detection of autoantibodies is a mainstay of diagnosing autoimmune hepatitis (AIH). However, conventional autoantibodies for the workup of AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty.
Taubert, Richard, Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina L., Behrendt, Patrick, Baerlecken, Niklas T., Sühs, Kurt-Wolfram, Janik, Maciej K., Zachou, Kalliopi, Sebode, Marcial, Schramm, Christoph, Londoño, María-Carlota, Habes, Sarah, UK-AIH Consortium, Oo, Ye H., Lalanne, Claudine, Pape, Simon, Schubert, Maren, Hust, Michael, Dübel, Stefan, Thevis, Mario, Jonigk, Danny, Beimdiek, Julia, Buettner, Falk F. R., Drenth, Joost P. H., Muratori, Luigi, Adams, David H., Dyson, Jessica K., Renand, Amédée, Graupera, Isabel, Lohse, Ansgar W., Dalekos, George N., Milkiewicz, Piotr, Stangel, Martin, Maasoumy, Benjamin, Witte, Torsten, Wedemeyer, Heiner, Manns, Michael P., Jaeckel, Elmar   +38 more
openaire   +9 more sources

The different factors influence on the serum immunoglobulms transformation into polyreactive immunoglobulins and their interaction with antigens [PDF]

Biopolymers and Cell, 1999
S A Bobrovnik
exaly   +2 more sources

Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo

Biomolecules, 2022
Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their ...
Anne K. Braczynski, Marc Sevenich, Ian Gering, Tatsiana Kupreichyk, Emil D. Agerschou, Yannick Kronimus, Pardes Habib, Matthias Stoldt, Dieter Willbold, Jörg B. Schulz, Jan-Philipp Bach, Björn H. Falkenburger, Wolfgang Hoyer   +12 more
doaj   +1 more source

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens [PDF]

The Ukrainian Biochemical Journal, 2018
The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal ...
S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

Inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine [PDF]

The Ukrainian Biochemical Journal, 2016
The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and ...
V. M. Danilova, R. P. Vynogradova, S. G. Torkhova   +2 more
doaj   +1 more source