Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans [PDF]
Infection and Immunity, 1997 Secretory immunoglobulin A (S-IgA) was investigated in human secretions for the presence of natural antibodies (Abs) acting as the first "immune barrier" to infection before induction or boosting of specific responses. These molecules could be the secretory counterpart of the natural Abs in serum that were previously shown by our laboratory to be ...
C P, Quan +4 more
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Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes [PDF]
Leukemia & Lymphoma, 2018 Polyreactive antibodies are a major part of natural antibody repertoire and can react with different types of antigens both from the host (e.g.
Sreenivasulu Gunti +7 more
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About the Department of Molecular Immunology, or why it is important to study immunological processes at the molecular level [PDF]
The Ukrainian Biochemical JournalThis review summarizes the scientific accomplishments of the Department of Molecular Immunology at the Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine over the period 1975–2025.
S. V. Komisarenko, S. I. Romaniuk
doaj +1 more source
Polyreactive Binding of Antibodies Generated by Polyclonal B Cell Activation. I. Polyreactivity Could be Caused by Differential Glycosylation of Immunoglobulins [PDF]
Scandinavian Journal of Immunology, 1997 The aim of this study was to gain knowledge of the pre‐immune repertoire with reactivity directed to the carbohydrate antigen dextran B512 (Dx). Polyclonal activation of spleen cells in mice has been estimated to be a method of revealing the available repertoire.
C, Fernández +4 more
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Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection [PDF]
, 2020 Immune responses against certain viruses are accompanied by auto-antibody production although the origin of these infection-associated auto-antibodies is unclear.
Jinzai, Hideyuki +11 more
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Natural antibodies – facts known and unknown
Central European Journal of Immunology, 2018 In contrast to adaptive antibodies, natural antibodies are present in a non-immunised organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural antibodies, which are developed as a result of the effect of the -Gal epitope ...
Joanna Palma +3 more
doaj +1 more source
Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States
, 2020 Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses.
Valentina N. Buneva +2 more
core +1 more source
Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer’s patches
Immunology, 1999 To understand the biological function of natural immunoglobulin A (IgA) antibodies in Peyer's patches (PP), we generated IgA monoclonal antibody (mAb) clones from the PP of normal, unimmunized, specific pathogen-free BALB/c mice and examined their reactivities by enzyme-linked immunosorbent assay (ELISA). Many of these antibodies reacted with more than
M, Shimoda, Y, Inoue, N, Azuma, C, Kanno
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Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, Volume 13, Issue 61, 3 November 2026.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
Approaches to allergy detection using aptasensors [PDF]
, 2007 1. Immunoglobulins and IgE Antibodies are glycoprotein molecules which are produced by plasma cells in response to an immunogen (1). They belong to a class of spherical proteins called globulins and are hence known as immunoglobulins (Igs).
Mascini, Marco +4 more
core +4 more sources