Results 21 to 30 of about 935 (127)

Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis

Frontiers in Immunology, 2018
Secretory immunoglobulins have a critical role in defense of the gastrointestinal tract and are known to act by preventing bacterial acquisition. A stringent murine model of bacterial infection with Salmonella enterica Typhimurium was used to examine ...
Blaise Corthésy, Justine Monnerat, Marius Lötscher, Cédric Vonarburg, Alexander Schaub, Gilles Bioley   +5 more
doaj   +1 more source

Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans [PDF]

Infection and Immunity, 1997
Secretory immunoglobulin A (S-IgA) was investigated in human secretions for the presence of natural antibodies (Abs) acting as the first "immune barrier" to infection before induction or boosting of specific responses. These molecules could be the secretory counterpart of the natural Abs in serum that were previously shown by our laboratory to be ...
C P, Quan, A, Berneman, R, Pires, S, Avrameas, J P, Bouvet   +4 more
openaire   +2 more sources

Development of simple detection method of polyreactive secretory immunoglobulin A in saliva

The Journal of Physical Fitness and Sports Medicine, 2022
The level of secretory immunoglobulin A (SIgA) in saliva is associated with the risk of upper respiratory infection and has been identified as a condition indicator for athletes and an indicator of mucosal immune function in the elderly. In addition, it has been suggested that non-specific polyreactive SIgA is present in human saliva and colostrum. The
Sun, Ziyue, Inai, Yuto, Koseki, Kyoko, Oikawa, Satoshi, Eda, Nobuhiko, Akama, Takao   +5 more
openaire   +2 more sources

Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes [PDF]

Leukemia & Lymphoma, 2018
Polyreactive antibodies are a major part of natural antibody repertoire and can react with different types of antigens both from the host (e.g.
Sreenivasulu Gunti, Sarah E.M. Herman, Raju V.S.R.K. Gottumukkala, Ying Xiong, Clare Sun, Gilberto N. Carmona, Adrian Wiestner, Abner L. Notkins   +7 more
openaire   +2 more sources

About the Department of Molecular Immunology, or why it is important to study immunological processes at the molecular level [PDF]

The Ukrainian Biochemical Journal
This review summarizes the scientific accomplishments of the Department of Molecular Immunology at the Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine over the period 1975–2025.
S. V. Komisarenko, S. I. Romaniuk
doaj   +1 more source

Polyreactive Binding of Antibodies Generated by Polyclonal B Cell Activation. I. Polyreactivity Could be Caused by Differential Glycosylation of Immunoglobulins [PDF]

Scandinavian Journal of Immunology, 1997
The aim of this study was to gain knowledge of the pre‐immune repertoire with reactivity directed to the carbohydrate antigen dextran B512 (Dx). Polyclonal activation of spleen cells in mice has been estimated to be a method of revealing the available repertoire.
C, Fernández, M E, Alarcón-Riquelme, M, Abedi-Valugerdi, E, Sverremark, V, Cortes   +4 more
openaire   +2 more sources

Natural antibodies – facts known and unknown

Central European Journal of Immunology, 2018
In contrast to adaptive antibodies, natural antibodies are present in a non-immunised organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural antibodies, which are developed as a result of the effect of the -Gal epitope ...
Joanna Palma, Beata Tokarz-Deptuła, Jakub Deptuła, Wiesław Deptuła   +3 more
doaj   +1 more source

Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer’s patches

Immunology, 1999
To understand the biological function of natural immunoglobulin A (IgA) antibodies in Peyer's patches (PP), we generated IgA monoclonal antibody (mAb) clones from the PP of normal, unimmunized, specific pathogen-free BALB/c mice and examined their reactivities by enzyme-linked immunosorbent assay (ELISA). Many of these antibodies reacted with more than
M, Shimoda, Y, Inoue, N, Azuma, C, Kanno
openaire   +3 more sources

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source