Gas Flow Shaping via Novel Modular Nozzle System (MoNoS) Augments kINPen-Mediated Toxicity and Immunogenicity in Tumor Organoids [PDF]
Cancers, 2023 Medical gas plasma is an experimental technology for anticancer therapy. Here, partial gas ionization yielded reactive oxygen and nitrogen species, placing the technique at the heart of applied redox biomedicine. Especially with the gas plasma jet kINPen, anti-tumor efficacy was demonstrated.
Torsten Gerling +2 more
exaly +7 more sources
Concept for Improved Handling Ensures Effective Contactless Plasma Treatment of Patients with kINPen® MED [PDF]
Applied Sciences, 2020 The nursing of patients with wounds is an essential part of medical healthcare. In this context, cold atmospheric-pressure plasma sources can be applied for skin decontamination and stimulation of wound healing.
Veronika Hahn +6 more
doaj +4 more sources
Investigating the Mutagenicity of a Cold Argon-Plasma Jet in an HET-MN Model. [PDF]
PLoS ONE, 2016 OBJECTIVE:So-called cold physical plasmas for biomedical applications generate reactive oxygen and nitrogen species and the latter can trigger DNA damage at high concentrations.
Susanne Kluge +7 more
doaj +3 more sources
The spatial density distribution of H2O2 in the effluent of the COST-Jet and the kINPen-sci operated with a humidified helium feed gas [PDF]
Plasma Sources Science and Technology, 2023 Abstract Cold atmospheric plasma jets operated with a helium feed gas containing small admixtures of water vapour are excellent sources of H2O2 for direct biomedical applications. However, H2O2 is typically distributed non-uniformly throughout the effluent region, meaning the dosage received by a patient or substrate is dependent on ...
B Harris +4 more
openaire +3 more sources
Absolute densities of O and O$$_3$$ in the effluent of an atmospheric pressure plasma jet (kINPen) operated with He and Ar determined by molecular beam mass spectrometry [PDF]
The European Physical Journal D, 2023 Abstract The absolute densities of O and O $$_3$$ 3
T. A. Hahn, J. Benedikt, H. Kersten
openaire +3 more sources
Nitrosylation vs. oxidation - How to modulate cold physical plasmas for biological applications. [PDF]
PLoS ONE, 2019 Thiol moieties are major targets for cold plasma-derived nitrogen and oxygen species, making CAPs convenient tools to modulate redox-signaling pathways in cells and tissues.
Jan-Wilm Lackmann +9 more
doaj +2 more sources
Ex Vivo Exposure of Human Melanoma Tissue to Cold Physical Plasma Elicits Apoptosis and Modulates Inflammation [PDF]
Applied Sciences, 2020 Cutaneous melanoma is the most aggressive type of skin cancer with a not-sufficient clinical outcome. High tumor mutation rates often hamper a remedial treatment, creating the need for palliative care in many patients.
Sander Bekeschus +8 more
doaj +2 more sources
Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood
Advanced NanoBiomed ResearchCold medical gas plasma promotes hemostasis through platelet activation, yet the underlying molecular and functional mechanisms remain incompletely understood.
Sander Bekeschus +5 more
doaj +2 more sources
A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions [PDF]
Plasma Chemistry and Plasma Processing, 2017 A comparative study of two plasma sources (floating-electrode dielectric barrier discharge, DBD, Drexel University; atmospheric pressure argon plasma jet, kINPen, INP Greifswald) on cancer cell toxicity was performed. Cell culture protocols, cytotoxicity assays, and procedures for assessment of hydrogen peroxide (H2O2) were standardized between both ...
Bekeschus, Sander +5 more
openaire +3 more sources
Feed Gas Composition and Humidity Shape Reactive Species Signatures in a Clinical Cold Plasma Jet
PlasmaReactive oxygen and nitrogen species (RONS) generated by medical gas plasmas are considered major mediators of plasma-induced biological effects. This includes the atmospheric pressure argon plasma jet kINPen routinely used in clinical applications.
Lingyun Yu +5 more
doaj +2 more sources