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KIR genes

Transplant Immunology, 2005
This review updates the on-going investigations into KIR genes and their alleles with the main emphasis on what has taken place in this laboratory over the last 3 years.
Derek, Middleton   +2 more
openaire   +2 more sources

KIRs mark killers suppressing autoimmunity

Immunity, 2022
Identification of regulatory CD8+ T cells that suppress pathological immune responses is an importunate pursuit. In a recent issue of Science, Li et al. demonstrated that human KIR+CD8+ T cells suppress autoimmunity by eliminating pathogenic CD4+ T cells.
June-Young, Koh, Eui-Cheol, Shin
openaire   +2 more sources

Human KIR sequences 2003

Immunogenetics, 2003
We have compiled the nucleotide sequences and their amino acid translations from a total of 89 Killer Immunoglobulin-like Receptor (KIR) alleles, derived from 17 different KIR genes. The alignments use the KIR3DL2*001 allele as a reference sequence. Each of the KIR sequences included in these alignments has been checked and where discrepancies have ...
C A, Garcia   +5 more
openaire   +2 more sources

“Self”-reflection by KIR

Blood, 2009
Abstract Significant debate exists over the proposed mechanisms by which NK receptor expression coordinates with the acquisition of function and titration of responsiveness, a process called NK-cell education. In this issue of Blood, Andersson and colleagues provide new insights into the mechanisms underlying NK-cell repertoire formation
Sarah, Cooley, Jeffrey S, Miller
openaire   +2 more sources

Role of KIRs and KIR ligands in hematopoietic transplantation

Current Opinion in Immunology, 2008
This review focuses on recent research demonstrating the role alloreactive natural killer (NK) cells play in adoptive immunotherapy of leukemia in allogeneic hematopoietic transplantation. For patients with hematologic malignancies and an indication to allogeneic hematopoietic transplantation who do not have a matched sibling donor, unrelated donor, or
openaire   +4 more sources

KIR shapes HLA

Human Immunology, 2015
Aim Receptor-ligand (KIR-HLA) interaction of natural killer (NK) cells with HLA antigens plays critical role in immune responses against viral infection and tumor transformation. Both gene families are highly polymorphic, their co-evolution and overall diversity is critical for population survival and reproduction.
Ketevan Gendzekhadze   +3 more
openaire   +1 more source

Chondrilla leiosperma Kar. & Kir.

2022
Published as part of Güzel, Murat Erdem, Kilian, Norbert, Sennikov, Alexander N., Coşkunçelebi, Kamil, Makbul, Serdar & Gültepe, Mutlu, 2022, Caucasoseris, a new genus of subtribe Chondrillinae (Asteraceae: Cichorieae) for the enigmatic Prenanthes abietina, pp.
Güzel, Murat Erdem   +5 more
openaire   +1 more source

A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs

Genes & Immunity, 2013
Analysis of killer cell immunoglobulin-like receptor (KIR) expression has been notoriously difficult because of the cross-reactivity of available antibodies, in particular between activating and inhibitory isoforms. We undertook a comprehensive study of available anti-KIR antibodies binding to activating KIRs (a-KIRs).
Czaja, K.   +5 more
openaire   +3 more sources

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