Results 1 to 10 of about 6,949 (166)

Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential [PDF]

Biomolecules
Chronic pain and mental health disorders, such as depression and anxiety, frequently co-occur and share underlying mechanisms involving neuronal excitability and synaptic transmission. The inwardly rectifying potassium channel 4.1 (Kir4.1), predominantly
Tingfeng Zha, Xinyi Fang, Jiamin Wan, Xiaoyan Chen, Jiu Lin, Qianming Chen   +5 more
doaj   +3 more sources

Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain [PDF]

Cell Reports
Summary: Intense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest ...
Olga Tyurikova, Olga Kopach, Kaiyu Zheng, Daman Rathore, Neela Codadu, Sheng-Yi Wu, Yi Shen, Robert E. Campbell, Rob C. Wykes, Kirill Volynski, Leonid P. Savtchenko, Dmitri A. Rusakov   +11 more
doaj   +3 more sources

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis [PDF]

Advanced Science
Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti‐Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential.
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
doaj   +3 more sources

Role of Glyoxalase in Astrocytes’ Supportive Function Under Hyperglycemic Conditions: Aminoguanidine and Kir4.1 Channel Recovery [PDF]

Brain Sciences
Background/Objectives: Diabetes mellitus is a metabolic disorder, and hyperglycemia results in abnormal brain function. Since glycolysis is the main energy pathway in glial cells, astrocytes possess a more developed glyoxalase (Glo) system than neurons ...
Jadier Colón-Vázquez, Nathaly M. Rosado-Rivera, Joshua J. Navedo-Jackson, Arelys A. Angueira-Laureano, Yanitza Hernandez-Santiago, Geronimo Maldonado-Martinez, Miguel P. Méndez-González, Misty J. Eaton, Serguei N. Skatchkov, David E. Rivera-Aponte   +9 more
doaj   +3 more sources

Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model [PDF]

Neural Regeneration Research
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells, which is involved in retinal ganglion cell apoptosis in glaucoma.
Fang Li, Zhen Li, Shuying Li, Hong Zhou, Yunhui Guo, Yongchen Wang, Bo Lei, Yanying Miao, Zhongfeng Wang   +8 more
doaj   +3 more sources

Acteoside relieves diabetic retinopathy through the inhibition of Müller cell reactive hyperplasia by regulating TXNIP and mediating Kir4.1 channels in a PI3K/Akt-dependent manner. [PDF]

PLoS ONE
Diabetic retinopathy (DR) is a severe microangiopathy of diabetes. Müller cells play an important role in the development of DR. Acteoside (ACT) has been reported to be effective in the treatment of DR.
Xiaoting Xi, Xiaolei Liu, Qianbo Chen, Jia Ma, Xuewei Wang, Yufei Gui, Yuxin Zhang, Yan Li   +7 more
doaj   +3 more sources

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β [PDF]

Journal of Neuroinflammation, 2012
Objective Decreased expression of inwardly rectifying potassium (Kir) channels in astrocytes and glioma cells may contribute to impaired K+ buffering and increased propensity for seizures. Here, we evaluated the potential effect of inflammatory molecules,
Zurolo Emanuele, de Groot Marjolein, Iyer Anand, Anink Jasper, van Vliet Erwin A, Heimans Jan J, Reijneveld Jaap C, Gorter Jan A, Aronica Eleonora   +8 more
doaj   +7 more sources

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease. [PDF]

Glia
Alzheimer’s disease (AD), particularly late-onset AD (LOAD), affects millions worldwide, with the apolipoprotein ε4 (APOE4) allele being a significant genetic risk factor.
Abhyankar SD, Xiao Y, Mahajan N, Luo Q, Cummins TR, Oblak AL, Lamb BT, Corson TW, Bhatwadekar AD.   +8 more
europepmc   +2 more sources

Astroglial Kir4.1 and AQP4 Channels: Key Regulators of Potassium Homeostasis and Their Implications in Autism Spectrum Disorders. [PDF]

Cell Mol Neurobiol
Astroglial Kir4.1 and AQP4 channels are pivotal regulators of potassium (K+) and water homeostasis in the brain, playing essential roles in maintaining neuronal stability, facilitating synaptic transmission, and supporting overall brain function.
Abbasian V, Davoudi S, Vahabzadeh A, Maftoon-Azad MJ, Janahmadi M.   +4 more
europepmc   +2 more sources

Mechanistic target of rapamycin complex-2 mediates the effect of overnight high K⁺ on Kir4.1/Kir5.1 in the DCT and ENaC/ROMK in ASDN. [PDF]

Am J Physiol Renal Physiol
We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule (early-CNT).
Duan XP, Zheng JY, Zhang CB, Alam S, Wang WH, Lin DH.   +5 more
europepmc   +2 more sources