Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype. [PDF]
, 2019 Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Kauffman, Alexander S +4 more
core +1 more source
The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates [PDF]
, 2014 Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (
Elphick, MR, Mirabeau, O
core +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Regulation and Possible Functions of Kisspeptin in the Medial Amygdala
Frontiers in Endocrinology, 2017 Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility.
Shannon B. Z. Stephens +1 more
doaj +1 more source
Hypothalamic Kisspeptin Neurons and the Control of Homeostasis.
Endocrinology, 2021 Hypothalamic kisspeptin (Kiss1) neurons provide indispensable excitatory transmission to GnRH neurons for the coordinated release of gonadotropins, estrous cyclicity and ovulation.
O. Rønnekleiv, J. Qiu, M. Kelly
semanticscholar +1 more source
Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach
The Chemical Record, EarlyView.This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos +3 more
wiley +1 more source
Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation [PDF]
Human Reproduction Update, 2018 Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include ...
Kai-Lun Hu +5 more
openaire +2 more sources
Hypothalamic KiSS1/GPR54 Gene Expressions and Luteinizing Hormone Plasma Secretion in Morphine Treated Male Rats [PDF]
International Journal of Fertility and Sterility, 2018 Background: The inhibitory effects of morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release.
Homayoun Khazali +2 more
doaj +1 more source
Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel +5 more
wiley +1 more source
Frontiers in Endocrinology, 2021 Traditionally, the anteroventral periventricular (AVPV) nucleus has been the brain area associated with luteinizing hormone (LH) surge secretion in rodents.
Xianhua Lin +6 more
semanticscholar +1 more source