Results 81 to 90 of about 6,216 (180)

Hyperalgesic Activity of Kisspeptin in Mice

Molecular Pain, 2011
Background: Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal cord, we examined the role of kisspeptin in the regulation of pain sensitivity in mice.
Spampinato S, Trabucco A, Biasiotta A, Biagioni F, Cruccu G, COPANI, Agata Graziella, Colledge WH, SORTINO, Maria Angela, Nicoletti F, CHIECHIO, SANTINA   +9 more
openaire   +4 more sources

Potential role of Kisspeptin in infertility [PDF]

BIO Web of Conferences
Kisspeptin is a neuropeptide that plays a central role in fertility and neuroendocrine regulation of the hypothalamic-pituitary-gonadal axis. It has also been shown to act at the peripheral level in both men and women.
Konaté Oumar, Mbaye Modou Mamoune, El Khalfi Bouchra, Bnkhalifa Moncef, Louanjli Noureddine, Soukri Abdelaziz   +5 more
doaj   +1 more source

Kisspeptin and Endometriosis—Is There a Link?

Journal of Clinical Medicine
This article presents a narrative review that explores the potential link between kisspeptin—a key regulator of the hypothalamic-pituitary-gonadal axis—and the pathogenesis of endometriosis. Kisspeptin plays a significant role in regulating reproductive functions by modulating the release of gonadotropin-releasing hormone (GnRH), which in turn ...
Blazej Meczekalski, Agata Nowicka, Stefania Bochynska, Aleksandra Szczesnowicz, Gregory Bala, Anna Szeliga   +5 more
openaire   +2 more sources

A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10

American Journal of Physiology-Endocrinology and Metabolism, 2010
The kisspeptins are neuropeptides that stimulate the hypothalamo-pituitary-gonadal (HPG) axis. The smallest endogenous kisspeptin, kisspeptin-10 (KP-10), binds to the receptor KISS1R with a similar affinity to the full-length peptide, kisspeptin-54 (KP-54), but is less effective in vivo, possibly because of increased enzymatic breakdown or clearance ...
Curtis, Annette E., Cooke, Jennifer H., Baxter, Jordan E., Parkinson, James R. C., Bataveljic, Attia, Ghatei, Mohammad A., Bloom, Stephen R., Murphy, Kevin G.   +7 more
openaire   +3 more sources

Functional studies of kisspeptin analogues and the human kisspeptin receptor

, 2023
Kisspeptins and their cognate receptor, the kisspeptin receptor, play pivotal roles in the regulation of the development of puberty and cancer metastasis. However, the signalling pathways activated by kisspeptins and the kisspeptin receptor remain largely to be demonstrated.
openaire   +1 more source

Kisspeptin Administration and mRNA Expression in Adult Syrian Hamsters

Cells
Kisspeptin (Kiss1) and kisspeptin 1 receptor (Kiss1R) are vital in regulating various functions across many species, primarily those relating to reproduction.
Megan A. L. Hall, Peyton L. Reeder, Johnathan M. Borland, Robert L. Meisel   +3 more
doaj   +1 more source

Astrocytes: a star emerges in the control of reproductive hormones

The Journal of Clinical Investigation
Kisspeptin is an essential neuropeptide sitting at the apex of the hypothalamo-pituitary-gonadal (HPG) endocrine axis to regulate gonadotropin-releasing hormone (GnRH) neurons and downstream reproductive hormones.
Ali Abbara, Waljit S. Dhillo
doaj   +1 more source

Kisspeptin in male reproduction

Journal of the Chinese Medical Association, 2021
Lee, Wen-Ling, Lee, Fa-Kung, Wang, Peng-Hui   +2 more
openaire   +4 more sources

Kisspeptin in female reproduction

Journal of the Chinese Medical Association, 2021
Lee, Wen-Ling, Lee, Fa-Kung, Wang, Peng-Hui   +2 more
openaire   +3 more sources

The translational use of Kisspeptin and kisspeptin receptor agonists in humans

, 2020
Kisspeptin is a neuropeptide that is known to be a critical regulator of hypothalamic gonadotrophin releasing hormone (GnRH). Physiological studies of kisspeptin have examined the effects of different kisspeptin isoforms (Kisspeptin-10, kisspeptin-54) on GnRH release in men and women.
openaire   +2 more sources